Antigen: peptide from the C-terminal region of human HIF-1α6
Host: rabbit
Species Reactivity: (+) human, mouse, and simian HIF-1α
Application(s): (+) WB
HIF-1α is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1α migrates to the nucleus where, with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however overexpression in cancer cells promotes tumor survival.