Cayman Chemical

The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. C6-HSL is a small diffusible signaling molecule involved in quorum sensing, controlling gene...

A potent, trichothecene mycotoxin produced by certain Fusarium strains that is toxic to fungi, plants, animals, and various mammalian tissue cultures via inhibition de novo protein synthesis.

Immunogen: Synthetic peptide from the N-terminal cytoplasmic region of human protein CB1 receptor Species Reactivity: human, mouse, and rat CB1 Host: Rabbit Application(s): (+) WB This antisera has been raised against the N-terminal (amino acids 1-14) extracellular region of the of the CB1 receptor,...

A fluorogenic substrate for activated caspase-3 (Km = 9.7 µM), as well as related caspases; caspase activity can be quantified by fluorescent detection of free AFC, which is excited at 400 nm and emits at 505 nm.

Ricinoleic acid methyl ester is a neutral, more lipophilic form of the free acid that can be used as an analytical standard for ricinoleic acid.

Antigen: human RICK amino acids 11-30 Host: rabbit Application(s): WB Overexpression of RICK promotes the activation of caspase-8 and Fas-induced apoptosis. RICK represents a novel kinase that regulates Fas-induced apoptosis.

Binds the peripheral benzodiazepine receptor, TSPO, with selectivity and high affinity (Ki = 3.1 nM in cerebellum, 4.1 nM in spinal cord); blocks binding of typical benzodiazepines to TSPO.

Contains the 16:0 fatty acid, palmitate, at the sn-1 position; at 25 μM inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers without affecting proliferation; at 0.1-25 μM significantly inhibits autotaxin.

A selective, irreversible inhibitor of IL-1b converting enzyme (ICE; Caspase-1); neuroprotective in a rat model of cerebral ischemia.

Antigen: Peptide from the C-terminal region of human dopamine β-hydroxylase (DBH) Host: sheep Cross Reactivity: (+) Human, mouse, and non-human primate tissue DBH Application: WB

15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.

Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro PGF2α. It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC₅₀ value of latanoprost...

A cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC₅₀ = 0.8 μM); inhibits HCT116 and NCI-H460 tumor cell growth (IC₅₀s 1 cell cycle arrest.

A benzoxazolone carboxamide that potently inhibits acid ceramidase (IC₅₀ = 79 nM); extremely stable in buffers and plasma and shows good pharmacokinetics when administered intravenously or intraperitoneally in mice, significantly reducing acid ceramidase activity in multiple organs.

An internal standard for the quantification of PGD2 by GC- or LC-MS.

2-carboxy-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.

An N-hydroxysuccinimide ester of the nitroxide spin label tempyo; an active acylating agent that preferentially targets α-amino groups, used to spin label proteins and aminoacylated RNA species.

(±)9(10)-DiHOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of (±)9(10)-DiHOME by GC- or LC-MS.

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli MW: 37.9 kDa

A major oxysterol formed from cholesterol by CYP3A4/5; used as a marker for CYP3A4/5 activity.

A selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously.

Antigen: human citrullinated fibrinogen Clone designation: 10E9.3 Host: mouse Cross Reactivity: (+) human Isotype: IgG2b Application(s): ELISA and WB

DAN-1 EE is a fluorescent indicator for the bioimaging of NO. DAN-1 EE is a cell permeable derivative of DAN, a molecule which has been used extensively in the quantitation of nitrate and nitrite using fluorescence spectroscopy. Upon entry into the cell, DAN-1 EE is transformed into the less cell...

A highly sensitive, stable substrate for HRP that reacts with H2O2 to produce the fluorescent compound resorufin; enables detection of H2O2 at a concentration as low as 5 pmol per 100 µl samples.