Cayman Chemical

A potent LTB4 receptor antagonist that inhibits the specific binding of [3H]-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM; inhibits the LTB4-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively.

An endogenous intermediate in the synthesis of phosphatidylcholine that demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders when administered exogenously.

An internal standard for the quantification of (S)-BEL by GC- or LC-MS.

An orally available inhibitor of SGLT1 and SGLT2 (IC₅₀s = 36 and 1.8 nM, respectively, for human isoforms in vitro); improves glycemic control in nonobese diabetes prone mice with type 1 diabetes and in patients with type 2 diabetes in a randomized, placebo-controlled clinical trial.

Selectively inhibits ALK1 (IC₅₀ = 46 nM) and ALK2 (IC₅₀ = 32 nM) with >300-fold selectivity over ALK3, ALK6, and VEGF type 2 receptor; inhibits BMP4 signaling with an IC₅₀ value of 152 nM in a functional assay.

A decomposition product of PGD2 in aqueous media in the presence of albumin; exhibits antitumor and antiviral activity, inhibiting growth of cultured L1210 cells (IC₅₀ = 0.7 µg/ml).

A potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC₅₀ values of 12.0, 12.1, and 10.9 nM, respectively; also blocks Notch signaling (IC₅₀ = 14.1 nM); modulates γ-secretase activity in vivo, altering Aβ...

A small molecule inducer of definitive endoderm from embryonic stem cells; induces the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC₅₀ = 223 nM in vitro) by activating the TGF-β signaling pathway.

An orally active synthetic derivative of the tryptophan metabolite anthranilic acid with varied immunological effects.

Antigen: human 15-LO-2 amino acids 161-179 Host: rabbit Cross Reactivity: (+) human 15-LO-2; (−) rabbit reticulocyte 15-LO-1 and porcine leukocyte 12-LO-1 Application(s): WB 15-LO-2 oxygenates C15 of arachidonic acid to produce 15(S)-HETE. Expression of 15-LO-2 appears to be restriced to...

A synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies.

A selective inhibitor of the Src family of non-receptor tyrosine kinases (IC₅₀s = 2 and 6 nM for Lck and Src, respectively); used in combination with PD 0325901, CHIR99021, and SB-590885 to support self-renewal of naïve human embryonic stem cells.

A synthetic curcuminoid with antioxidant and anticarcinogenic properties; increases the activity of quinone reductase in mouse hepatoma cells in a dose-dependent fashion, doubling activity at 0.3 μM salicylcurcumin.

Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost lactone diol is an intermediate in the synthesis of latanoprost. Latanoprost lactone diol can be converted to the free acid of latanoprost by reduction with DIBAL followed by...

A substrate of IMPDH, a NAD+-dependent enzyme that generates xanthosine monophosphate in a rate-limiting step in DNA, RNA, and glycoprotein synthesis; also involved in potentiating the umami taste sensation.

A potent antagonist of dopamine receptors (IC₅₀s = 1.0 and 0.9 nM for D2 and D3, respectively);,also avidly binds α1- and α2-adrenergic receptors, histamine H1 receptor, and serotonin (5-HT) receptors 5-HT1D and 5-HT2A (Kis = 10, 80, 3.4, 19, 1.2 nM, respectively).

A sulfonylurea compound which acts as an inhibitor of ATP-dependent inwardly-rectifying K+ channels (IC₅₀ = 4.3 nM); stimulates insulin secretion from beta cells.

A cephalosporin antibiotic that is effective against E. coli (MIC values range from 0.25-2 mg/L depending on strain) as well as H. influenza and S. aureus.

A potent water-soluble agonist of CB1 and CB2 receptors with Ki values of 1.5 and 0.32 nM, respectively; when dissolved in saline, is highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly.

A flavonoid compound that acts as a powerful antioxidant; inhibits TBARS formation with an IC50 value of 6.34 µM; blocks oxLDL uptake by U937-derived macrophages at 20 µM; demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit neoplastic transformation of murine...

A metabolically stable analog of the anti-inflammatory endogenous CB, PEA; inhibits FAAH-mediated hydrolysis of AEA by 54% at a concentration of 100 µM; has weak CB receptor affinity, in that 100 µM inhibits agonist binding (1 nM CP 55,940 or WIN 55,212-2) only 26% and 15.5% at the human...

An inhibitor of PARP (IC₅₀ = 180 nM); blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation.

A potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM) and the common activating mutants of p100α (E542K, E545K, and H1047R) found in cancer; prevents proliferation in BT474 tumor xenografts and reduces MAPK signaling with twice daily dosing at 25...

A cell permeable drug that inhibits cholesterol trafficking from late endosomes/lysosomes to the ER, but not to the plasma membrane.