Cayman Chemical

A fatty acid glycerol that has been isolated from S. chinensis roots, inhibits PAF-AH with an IC50 value of 45 µM.

A selective S1P1 receptor agonist in both human and mouse.

A selective, reversible inhibitor of FAS (pIC₅₀ = 7.8).

A mycotoxin that inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.

CAT is a ubiquitous antioxidant enzyme involved in the detoxification of H2O2, a toxic product of both normal aerobic metabolism and pathogenic ROS production. It catalyzes the conversion of two molecules of H2O2 to molecular oxygen and two molecules of water (catalytic activity). CAT also...

A synthetic H2S donor that can be readily esterified with other moieties, including therapeutics and targeting motifs; used both in cells and in animals for comparative studies with derived chimeras.

A light-emitting biomolecule that serves as a substrate for luciferases or constituent of photoproteins;,oxidation to coelenteramide is accompanied by emission of blue light (emission maximum = 460-470 nm); used in BRET studies and to detect changes in calcium level and redox status.

Host: rat Cross Reactivity: (+) human podoplanin (Clone NZ-1.2) Application(s): FC and WB Podoplanin is expressed in many tumors and many normal cells, especially lymphatic epithelial cells and follicular DC. Expression is positively correlated with tumors expressing greater invasive and metastatic...

A 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation; increases integrin-dependent attachment of hESC to extracellular matrices.

Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PAD enzymes catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. All enzymes are cytosolic except for...

An immunosuppressant used to prevent transplant rejection; potent inhibitor of IL-2 activation of lymphocytes (IC50 = 5 pM); specifically interacts with FKBP12 to form a complex which inhibits mTORC1.

An orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC₅₀s = 105 nM and 24 µM, respectively); increases motility of microvascular endoethelial cells; alters cell function and inflammatory responses in vivo.

Formal Name: 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-pyrano[2,3-c]pyrazole-5-carbonitrile CAS Number: 1637739-82-2 Molecular Formula: C₁₆H₁₃F₃N₄O Formula Weight: 334.3

Protein arginine deiminase 4 (peptidylarginine deiminase 4 (PAD4)), is a guanidino-modifying enzyme which catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 activity is increased in rheumatoid arthritis (RA), producing citrulline-containing...

A S-nitrosothiol that acts as an NO donor under acidic conditions; decomposes with a half-life of 6 minutes in 0.1 M phosphate buffer, pH 5.0, at 37°C; relaxes phenylephrine-constricted rat aortic strips 35% and 8% at pH 6.0 and 7.4, respectively.

Immunogen: Peptide from the C-terminal region of human TP receptor Host: Rabbit Species Reactivity: (+) human, COS-7 (African green monkey), mouse, and rat TP receptor Application(s): ICC and WB The TP receptor is a GPCR that mediates the action of TXA2.

An analytical reference standard categorized as a phytocannabinoid; considered an impurity in commercial preparations of cannabidiol; intended for research and forensic applications

A nonselective inhibitor of the mitochondrial F1FO ATP synthase that can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.

A natural plant flavonoid.

Antigen: human TLR3 amino acids 55-70 Host: mouse, clone 40C1285.6 Cross Reactivity: (+) human and canine TLR3 Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB TLR3 has a restricted expression pattern being expressed in dendritic cells. The expression of TLR3 in a single...

A potent cell-permeable inhibitor of ERK1 and ERK2 (Ki = 310 and 140 nM, respectively); much less effective against p38α (IC₅₀ = 10 µM) and does not inhibit a range of other serine/threonine or tyrosine kinases; blocks ERK-mediated signaling from TGF-β to AP-1...

A selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) channels (EC₅₀s = 230 and 510 nM for KCNQ2 and KCNQ4, respectively) that demonstrates > 80-fold selectivity against other related K+ potassium channels.

An internal standard used in the quantitative analysis of risperidone.

This assay system utilizes HEK293t cells that express NF-κB (nuclear factor kappa-lightchain enhancer of activated B cells) and contain the luciferase reporter gene functionally linked to upstream NF-κB genetic response elements. Thus, quantifying changes in luciferase expression...