Cayman Chemical

A potent inhibitor of all HDACs, with Ki values ranging from 0.6 to 31 nM for HDAC1-11; leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells; has potential applications in spinal muscular atrophy and HIV therapy.

An imidazoquinoline compound that activates TLR7 (EC₅₀ = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators; up-regulates the OGF receptor on cancer cells, blocking cell proliferation (IC₅₀ = 2 µM).

Antigen: CRTH2/DP2 protein amino acids 2-21 Host: rabbit Cross Reactivity: (+) human, mouse, and rat DP2 receptor Application(s): ICC and WB

An inactive metabolite of artemisinin.

A pan Akt inhibitor (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation; slows the progression of Akt-dependent tumors in vivo; concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction.

A flavonoid found in licorice root that displays antioxidant, anti-inflammatory, and antitumor activities; induces quinone reductase-1 with a concentration required to double activity of 1.8 μM in mouse hepatoma cells.

An inhibitor of EGF receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.

A synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE; significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM).

A non-nucleoside reverse transcriptase inhibitor that binds to viral reverse transcriptase and blocks polymerase activity by preventing RNA plus-strand initiation (IC₅₀s = ~ 0.45 to 0.9 μM).

An autophagy inhibitor that has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification at a minimum concentration of 0.5 µM.

A selective inhibitor of Src family kinases, with IC₅₀ values for Src, Lck, Lyn, and Hck of 9, 3, 3, and 0.43 nM, respectively; induces growth arrest and apoptosis in chronic myelogenous leukemia cell lines; prevents differentiation while maintaining pluripotency in embryonic stem cells.

Used to cyanylate proteins and to specifically cleave the amino-terminal peptide bond of cysteine residues.

Peptide Sequence: human EP3 receptor sequence amino acids 308-327 (NQTSVEHCKTHTEKQKECNF) To be used in conjunction with Cayman’s EP3 receptor polyclonal antibody (Catalog No. 101760) to block protein-antibody complex formation during immunochemical analysis for the EP3 receptor.

15(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. The biosynthesis of 15-HEPE from EPA in guinea pig epidermal enzyme preparations has been documented. 15(S)-HEPE generated by soybean lipoxygenation of EPA inhibits RBL-1 cell 5-LO with an IC₅₀ value of 28...

Inhibits the HIV-1 protease (IC₅₀ = 0.41 nM; Ki = 0.24 nM); used as a component of HAART to treat HIV infection and AIDS.

Initiates glycogen synthesis in hepatocytes by causing inactivation of phosphorylase a and activation of glycogen synthase a (maximal effects with ~20 µM Itu); potent inhibitor of ERK2 (Ki = 525 nM).

A certified reference material categorized as a phytocannabinoid; has been found in strains of Cannabis; a precursor in the biosynthesis of tetrahydrocannabivarin; provided as a DEA exempt preparation; intended for research and forensic applications

An antifungal agent that acts as an inverse agonist to disrupt Hh signaling (IC₅₀ = 0.8 μM); treatment at 100 mg/kg twice per day has been shown to suppress the growth of medulloblastomas from a Ptch+/-p53-/- mouse allograft model.

A ligand for serotonin receptors, acting as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC₅₀ values of 6 and 1 nM, respectively; binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT (Kis = 120 and 100 nM, respectively).

This assay product utilizes proprietary human cells engineered to provide constitutive, highlevel expression of the Human Pregnane X Receptor (NR1I2), a ligand-dependent transcription factor commonly referred to as PXR. PXR is also known as the Steroid and Xenobiotic sensing nuclear receptor (SXR)....

A synthetic peptide inhibitor of PKA (Ki = 1.7 nM).

A sulfonamide antibiotic that is bacteriostatic against gram-positive and gram-negative bacteria by restricting the production of folic acid, which is essential for bacterial growth.

A cysteine sulfoxide constituent of garlic that exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities; S-allyl-cysteine is oxidized stereospecifically to (+)-alliin by garlic tissue cultures.

A potent inhibitor of actin incorporation into filaments; also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.