Cayman Chemical

Source: recombinant N-terminal His-tagged protein expressed in E. coli MW: 19 kDa

A selective, positive allosteric modulator of mGluR1, enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16); directly activates mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC50 = 6.2 nM).

An antibiotic which inhibits MetAp2 with an IC50 value of 10 nM; inhibits angiogenesis by impairing the growth of endothelial cells; impairs microsporidial replication and can be used to treat microsporidial infections in immunocompromised patients; reduces diet-induced adipose tissue formation in...

An ester of a naturally occurring phenolic compound that demonstrates antihyperglycemic and antidiabetic activity as well as induces anti-inflammatory and antinociceptive effects.

A nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC₅₀s = 4.6 and 3.6 nM in rat and human, respectively); blocks adenosine uptake, thereby potentiating the interaction of extracellular adenosine with purinoreceptors.

Hydroxy linoleins are a mixture of 132 possible isomers of mono-, di-, and tri-hydroxy compounds produced by the autoxidation of trilinolein and subsequent reduction of the hydroperoxides. Autoxidation of linoleic acid containing triglycerides (i.e., trilinolein) in vivo could result in the...

An ionophore antibiotic isolated from certain Streptomyces sp. used in veterinary practice as a coccidiostat for gastrointestinal parasites.

Produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation; metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2.

Molecular Formula: C₂₃H₂₅Cl₂N₃OS

An endogenous, maturation-inducing steroid that at 1 µg/ml induces germinal vesicle breakdown in oocytes from several teleost species; can also influence spermiation by stimulating milt production when administered at 5 mg/kg to various male teleosts.

Inhibits KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively; also inhibits EGFR kinase (IC₅₀ < 10 nM), reducing proliferation of EGFR-dependent cancer cells.

A metabolite of progesterone and an inactive isomer of allopregnanolone, a positive modulator of GABAA receptors.

Human therapeutic antibodies have become increasingly common components of early drug discovery and development portfolios in the pharmaceutical and biotech industries. As part of preclinical toxicology assessment of these agents, they are routinely tested in non-human primates, primarily in rhesus...

An NSAID that inhibits both COX-1 (IC₅₀ = 113 µM) and COX-2 (IC₅₀s = 8.2 and 134 µM for human whole blood assay and human-modified whole blood assays, respectively).

Antigen: human PrP amino acids 106-126 Host: mouse, clone Pri 308 Isotype: IgG Application(s): IHC and WB

A SMO agonist (EC50 = 3 nM) which inhibits hedgehog signaling at high concentrations (>1 μM); directly binds to SMO and can block SMO inhibition by cyclopamine; at 15-240 nM, prevents the neurotoxic effects of glucocorticoids; at 0.4 mM, improves the conversion of iPSC to the neural lineage.

A hybrid of selenium and an NSAID that has been shown to reduce the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells (IC₅₀ = 3.4 µM); inhibits the cell cycle in G1 and G2/M phases and induces apoptosis by activating caspase 3/7 and PARP cleavage.

A potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC₅₀s = 23 and 26 nM, respectively); effective in vivo in mice.

A cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin E (IC₅₀s = 6 and 9 nM, respectively); blocks the cycling of HCT116 cells (EC₅₀ = 0.29-0.49 µM).

STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Item No....

Antigen: recombinant human IL-33 Host: mouse Cross Reactivity: (+) human IL-33; (−) mouse IL-33 Application(s): ELISA, IHC, IP, and WB IL-33, a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell...

A selective class I c-Met kinase inhibitor (Ki = 4.8 nM) that inhibits tumor cell proliferation, survival, and migration/invasion in MET-amplified cell lines in vitro (IC₅₀s = 12-31 nM); shows antitumor activity in in vivo tumor models harboring either MET gene amplification or a...

An internal standard for the quantification of LTA4 methyl ester by GC- or LC-MS.

An ABAH that specifically and irreversibly inhibits the peroxidation activity of myeloperoxidase (IC₅₀ = 0.3 μM); can be used with enzyme preparations, in cell cultures, and also in vivo.