Cayman Chemical

Impurity assessment is a key step during the drug development production of recombinant proteins, including therapeutic proteins. Specific impurities coming from the cells mediating the protein expression, known as ‘Host Cell Proteins (HCP)', are generated and need to be removed. This kit...

An ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC₅₀s = >20 µM).

An antiproliferative agent that presumably modulates xenobiotic-metabolizing enzymes, such as inhibiting CYP450, and/or induces phase II detoxifying enzymes.

Curcumin is an extract of turmeric root with antioxidant, anti-tumor, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages.

Antigen: recombinant mouse L-PGDS Host: rabbit Cross-reactivity: (+) human and mouse L-PGDS Applications: WB and IHC

A plant alkaloid that demonstrates cytotoxicity against leukemia P-388 cells (IC₅₀ = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.

Inhibits HDAC activity much more potently (IC₅₀ = 13 µM) than valproic acid (IC₅₀ = 398 µM); induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM; induces the expression of Hsp70-1a and Hsp70-1b and protects cerebellar granule...

A synthetic intermediate useful for pharmaceutical synthesis.

A fluorinated antibiotic related to chloramphenicol and thiamphenicol, used primarily in veterinary medicine.

A cell-permeable, reversible inhibitor of HDACs (IC50 = 30 nM).

An intermediate product in the synthetic pathway of biopterin that is released from macrophages upon immune stimulation with interferon-γ from activated T cells; routinely used as a biochemical tool to screen for and monitor the progression of certain diseases accompanied by hyperimmune...

An AT1 receptor antagonist (Ki = 5-20 nM); attenuates vein graft atherosclerosis in rabbits and reduces arterial blood pressure in rats; controls hypertension while protecting renal function, in humans.

Antigen: His-tag recombinant mouse Dnmt3a expressed in bacteria Isotype: IgG1 Host: mouse, clone 64B814.1 Cross Reactivity: (+) human and mouse DNMT3a Application(s): ELISA The DNMT3 family members DNMT3a and DNMT3b are strongly expressed in embryonic stem cells. Their expression is down regulated...

A hybrid molecule of an H2S donor and the NSAID diclofenac that does not cause gastric damage or promote leukocyte adherence to vascular endothelium; exhibits efficacy at doses of 10-50 µmole/kg in rat.

A reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2 (IC50 = 4 and 20 µM, respectively).

A panaxatriol that has diverse in vitro and in vivo effects, including neuroprotective, pro-angiogenesis, anti-inflammatory, and hypertensive actions in clinical trials.

A major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization; used as a biomarker to assess endogenous production of PGD2.

A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus.

A potent inhibitor of enkephalin convertase (Ki = 8.8 nM) that is functional in vivo; can also inhibit other carboxypeptidases, including TAFI.

A type B trichothecene mycotoxin found in cereals contaminated with certain Fusarium species.

A topoisomerase I inhibitor that is cytotoxic to HT-29 cells (IC₅₀ = 19 nM), induces DNA damage in whole cells (at 85 nM), and demonstrates significant anti-tumor activity.

A streptogramin antibiotic that is usually combined with another streptogramin antibiotic, dalfopristin, to synergistically kill Gram-positive bacteria.

Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo PGE1 is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. 13,14-dihydro-15-keto PGE1 itself is a...

Antigen: murine COX-1 amino acids 274-288 Host: rabbit Cross-Reactivity: (+) mouse and rat COX-1; (−) human and ovine COX-1, COX-2 (all species) Application(s): WB and IHC