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A very potent agonist of EP4, binding with a Ki value of 1.2 nM; does not bind EP1, EP2, EP3, DP, FP, IP, or TP receptors.
An analytical reference standard categorized as a synthetic cannabinoid; an isomer of (–)-?9-THC; provided as a DEA exempt preparation; intended for research and forensic applications
A methyl ester version of RvD2 which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.
Antigen: peptide corresponding to amino acid residues from the N-terminal region of rat PSD95 Host: rabbit Cross Reactivity: (+) rat and mouse PSD95; expected to react with bovine, human, non-human primates, and zebrafish PSD95 Application: WB
A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of Abn-CBD in vitro and in whole animals; blocks the...
Antigen: synthetic peptide from human FABP3 amino acids 44-55 Host: mouse Cross Reactivity:(+) human and rat FABP3, (−) mouse FABP3, other species not tested Application(s): WB (1:200 dilution); other applications not tested
A nitroaniline fatty acid amide used to measure FAAH activity; exposure to FAAH activity results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm) allowing the fast and convenient measurement of FAAH activity using a 96-well plate spectrophotometer.
A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.6 nM).
A pyridine alkaloid formed by the methylation of the nitrogen atom of niacin; used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes; inhibits the migration of hepatocarcinoma cells and renders them more susceptible to apoptosis by reducing Raf/ERK/Nrf2...
The S enantiomer of 9-PAHSA.
An antibiotic isolated from a strain of Streptomyces; inhibits DNA synthesis in bacteria and suppresses the growth of transplantable tumors in mice.
An internal standard for the quantification of ent-8-iso-15(S)-PGF2α by GC- or LC-MS.
A major urinary metabolite of PGF2α.
An analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position, allowing diverse chemical reactions, including click chemistry and polymerization; can be labeled with technetium-99m for analytical and diagnostic procedures.
An antagonist of the α3β4 nicotinic acetylcholine receptor subtype (IC50 = 10.2 μM); selectively binds the α3β4 subtype, compared to the α4β2 and α7 subtypes (Ki values of 0.508, >100, and >100 μM, respectively).
Sodium Phosphate Stock Solution (500 mM, pH 6.0) contains filtered sodium phosphate (500 mM, pH 6.0). It is ready to use as supplied.
A flavonoid that inhibits FAS, reducing IGF-1-induced activation of STAT3 in several melanoma cell lines.
An internal standard for the quantification of C6-HSL by GC- or LC-MS.
A selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay (pA2 = 8.1); demonstrates analgesic activity in a mouse writhing assay (ED50 = 0.9 mg/kg); potentiates the vasorelaxation of human pulmonary vein induced by PGE2 (EC50 = 7.75 µM).
11β-PGE1 is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. It is 13% and 3.6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum, respectively.
An orally-bioavailable dual inhibitor of CDK4 and CDK6 (IC50s = 2 and 10 nM, respectively); has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
Molecular Formula C11H14ClN • HCl Formula Weight 232.2
An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.
Produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA; has analgesic activities in whole animal experiments, yet is a very poor ligand for the CB1 receptor.