Cayman Chemical

Host: mouse, clone RIV7 Cross Reactivity: (+) human CD4 Application(s): (+) FC, ICC, and IHC (frozen sections); (−) IHC (paraffin-embedded tissue) and WB Isotype: IgG2a

A selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors) that has sedative, antinociceptive, analgesic, and hypothermic actions; additive or synergistic with fentanyl-type opioids in reducing pain; has anesthetic sparing properties.

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respectively.

A TrkB receptor antagonist that prevents activation of the receptor by BDNF (IC₅₀s = 45.6 nM and 41.1 μM for the high and low affinity sites of the receptor, respectively); demonstrates antianxiety and antidepressant properties in mouse models.

An Hsp90 inhibitor (IC₅₀s = 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and GRP94, respectively); dissociates the Hsp90-p23 complex, depleting the client protein c-Met and inducing Hsp70 in c-Met amplified GTL-16 gastric tumor cells; inhibits proliferation of various human tumor...

A member of the InsP family of small, soluble second messengers; inhibits Ins(3,4,5,6)P4 kinase activity to increase the cellular level of Ins(3,4,5,6)P4.

A potent, cell-permeable, and selective inhibitor of CDKs (IC₅₀s = 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively); reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell...

A SSRI which is commonly prescribed as an antidepressant; also acts as an antagonist of nicotinic acetylcholine receptors (IC₅₀ = 0.93 µM).

An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations; less potently blocks TRPC5 (IC₅₀ = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels.

An inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription; suppresses IL-6-induced phosphorylation of STAT3 in T cells (IC₅₀ = 38 μM) and is protective against angiotensin II-induced vascular dysfunction.

A Hh pathway inhibitor that suppresses signaling through Sonic Hh (IC₅₀ = 1.5 µM) without affecting Wnt signaling (IC₅₀ ≥ 30 µM); suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression; also inhibits signaling through the...

A 2-acetamidopyranoside that selectively inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM; reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis when used at 1 mg/kg in vivo.

A stable analog of PGF2α 2-glyceryl ester incorporating an activity-enhancing 17-phenyl substitution.

The major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 isoforms CYP1A2 and CYP3A4; inhibits the binding of testosterone to the nuclear androgen receptor (IC₅₀ = ~300-900), blocking the expression of AR target genes.

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension. At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats. The...

A nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent to form interstrand crosslinks in DNA, which leads to cancer cell cytotoxity and apoptosis; also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 and phospho-Tyr204 of rat ERK/MAPK Host: rabbit Cross Reactivity: (+) human and rat ERK/MAPK Application(s): WB ERK/MAPK is an integral component of cellular signaling during mitogenesis and differentiation...

A potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM); has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors.

Source: Active recombinant N-terminal His-tagged protein expressed in Sf21 cells Mr: 76.4 kDa Platelet-type 12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid.

A small molecule activator of a G protein-coupled bile acid receptor (pEC₅₀ = 6.8-7.5) that is reported to improve GLP-1 secretion by increasing intracellular cAMP levels; used to investigate the signaling, trafficking, and regulation of TGR5 receptors in order to identify potentially...

The reduced form of α-lipoic acid that acts as a general antioxidant at concentrations ranging from 0.01-0.5 mM; at 50-100 µM, triggers apoptosis of mouse embryonic stem cells and human cancer cells, suppressing proliferation.

A tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity (Ki = 400 nM) with minimal effect on the related GSTα and -µ families (Kis range from 20-75 µM); restores JNK-mediated cellular proliferation and differentiation signaling pathways.

A form of tafluprost which may have increased lipid solubility compared to the free acid.