Cayman Chemical

An intermediate in several metabolic pathways, including glycolysis and gluconeogenesis.

An immunosuppressive drug that inhibits DHODH (IC₅₀s = 0.134, 1.29, and 10.6 µM for human, rat, and mouse isoforms, respectively); inhibits the proliferation of T cells and B cells and the secretion of IL-17 (IC₅₀s = 12.9, 3.7, and 6.0 µM, respectively, in human...

An internal standard for the quantification of 4(Z),7(Z),10(Z),13(Z)-hexadecatetraenoic acid by GC- or LC-MS.

A potent TP receptor agonist; induces human platelet aggregation with EC₅₀ values of 0.34 and 0.17 nM at pH 7.4 and pH 6.0, respectively.

A fluorogenic substrate used to assay neuraminidase activity.

A synthetic analog of natural PtdIns containing C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

An orally bioavailable inhibitor of PI3K p110β that decreases cell viability and Akt phosphorylation in p100β-dependent PTEN-deficient PC-3 prostate and BT549 and HCC70 breast cancer cell lines.

A potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM); reduces the degradation of ubiquitin-conjugated proteins in extracts; blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of...

Antigen: synthetic peptide within the region of human TIP60 amino acids 480-530 Host: rabbit Cross Reactivity: (+) human (isoform CRA_b), chimpanzee, orangutan, equine, canine, mouse, ovine, rat, opossum, zebrafish, and Xenopus TIP60 Application(s): IHC and WB TIP60 belongs to the MYST family of...

A 1,4 cyclic ester derived from 4,5-DiHDPA, which is produced by epoxidation of DHA at the α-4 double bond.

A potent JAK2 inhibitor (Ki = 0.45 nM in vitro) that decrease STAT3/5 phosphorylation and inhibits cell proliferation (GI50 = 33 nM) in a JAK2 V617F mutated cell line; induces apoptosis in human T cell lymophotropic virus type 1-infected (IC₅₀ = ~1 µM), downregulating phosphorylated...

19(R)-Hydroxylated prostaglandins occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R). 19(R)-Hydroxylated prostaglandins are also...

A highly sensitive peptide substrate for both human and mouse neutrophil elastase and PR3.

A synthetic intermediate useful for pharmaceutical synthesis.

AG-99 is an inhibitor of EGF receptor kinase with an IC50 value of 10 µM in the human epidermoid carcinoma cell line A431.

An internal standard for the quantification of resolvin D1 by GC- or LC-MS.

A potent, selective inhibitor of ATR (IC₅₀ = 5 nM); inhibits the growth of LoVo colorectal adenocarcinoma cells in vitro and significantly reduces the growth of LoVo xenografts in mice.

An irreversible, mechanism-based inhibitor of lysine-specific demethylase 1 (LSD1) with an IC50 value of 20.7 µM and a Ki value of 242.7 µM that effectively inhibits histone demethylation in vivo; irreversibly inhibits monoamine oxidases (MAO) A and MAO B with IC50 values of 2.3 and 0.95...

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 65.5 kDa

A widely used synthetic antioxidant found in all types of manufactured items from foodstuff to cosmetics to rubber and paint.

Cayman’s Lipid Hydroperoxide Assay measures the hydroperoxides directly utilizing the redox reactions with ferrous ions. An easy to use quantitative extraction method was developed to extract lipid hydroperoxides into chloroform, and the extract is directly used in the assay. This procedure...

Prevents the interaction of PD-L1 with PD-1 with an IC₅₀ value of 18 nM.

A synthetic intermediate for pharmaceutical synthesis.

A selective, reversible inhibitor of V-ATPases in mammalian, plant, or fungal cells with an IC₅₀ value in the 4-400 nM range; at 100 nM, the related bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation.