Cayman Chemical

Antigen: peptide from the internal region of human GPR43 Host: rabbit Cross Reactivity: (+) human GPR43 Application(s): FC, IF, and WB

A DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins.

A potent agonist of GPR119 (EC₅₀s = 2.7 and 33 nM for human and rat forms, respectively); significantly reduces blood glucose and glycated hemoglobin levels in Zucker diabetic fatty rats.

An analog of D-erythro-sphingosine; inhibits PKC in mixed micelle assays with 50% inhibition at 2.2 mol % making it a more potent inhibitor compared to D-erythro-sphingosine or other analogs of shorter alkyl chain length.

A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC₅₀ = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft...

A major metabolite of nicotine that is often used as a biomarker to detect tobacco use; binds nicotinic- and muscarinic-type acetylcholine receptors and demonstrates antipsychotic drug-like properties and neuroprotective properties.

A precursor in the biosynthesis of coenzyme A.

Antigen: synthetic peptide from human LSD1 amino acids 450-500 Host: rabbit Cross Reactivity: (+) chimpanzee, bovine, canine, equine, human, mouse, orangutan, and porcine LSD1 Application(s): WB LSD1 is a lysine-specific histone demethylase that acts as a component of CoREST and other...

An orally bioavailable inhibitor of mPGES-1 (IC₅₀ = 0.24 µM in an in vitro human whole blood assay); inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively).

A monohydroperoxy PUFA produced from arachidonic acid by 12-LO.