Cayman Chemical

A trihydroxybenzoic acid that demonstrates antioxidant activity by scavenging DPPH• and HO• (IC50s = 9.4 and 191 μM, respectively) and inhibiting microsomal lipid peroxidation (IC50 = 1.51 μM).

Molecular Formula: C₁₃H₉ClFNO₂

A cell-permeable, ATP-competitive inhibitor of FLT3 (IC₅₀ = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC₅₀ = 0.41 µM).

Creatinine is commonly measured in urine and is a key benchmark for the normalization of a variety of urinary biomarkers. Serum creatinine levels, however, are a useful indicator of renal function and abnormal levels have been implicated in diabetes, cardiovascular, and circulatory diseases....

A trihydroxy fatty acid containing a conjugated tetraene produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes; promotes leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.

A fluorescent probe for any protein with a high affinity binding interaction with inositol-(4,5)-triphosphate phospholipids, such as PI-3-kinase, PTEN, or PH-domain-containing proteins.

The less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol.

Cayman’s PGE2 Express ELISA is a competitive assay that permits the rapid measurement of PGE2 from biological samples, requiring only 1 hour incubation and development times for each step. The foundation of the assay is Cayman’s high-affinity, well-characterized PGE2 monoclonal, the same...

A synthetic intermediate useful for pharmaceutical synthesis.

A cGMP-specific phosphodiesterase inhibitor that moderately inhibits PDE5 and PDE6 with IC50 values of 0.5-0.76 and 0.15 µM, respectively.

Early screening of a drug candidate’s potential to induce or inhibit CYP2B6 is a critical step in the drug development process. Cayman's CYP2B6 Induction Reporter Assay Kit is a novel method to evaluate human Constitutive Androstane Receptor 3 (hCAR3)-mediated CYP2B6 induction for the...

A purine derivative that reversibly antagonizes aryl hydrocarbon receptor signaling (IC50 = 127 nM in CD34+ cells); induces a 50-fold increase in human embryonic stem cells expressing CD34 (EC50 = 120 nM) and a 17-fold increase in stem cells that retain the ability to engraft immunodeficient mice.

A nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoid X receptor gamma (NR2B3), a ligand-dependent transcription factor commonly referred to as RXRG or RXRγ. INDIGO’s reporter cells include...

The linoleic acid Quant-PAK has been designed for the convenient, precise quantification of linoleic acid by GC- or LC-MS. It includes a 50 µg vial of linoleic acid-d4 and a precisely weighed vial of unlabeled linoleic acid, with the precise weight (2-4 mg) indicated on the vial. This...

A selective inhibitor of PI3Kγ

A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM).

Inhibits actin polymerization; uniquely inhibits HIV-1 protease (IC50 = 3 μM); rapidly and reversibly inhibits glucose transport by competitively binding glucose transporters (Ki = 4.0 μM); induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.

A selective, brain-accessible GABAB receptor antagonist (IC₅₀ = 34 µM).

(±)13-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via 11(R)-LO. (±)13-HDHA is a potential marker of oxidative stress...

Molecular Formula: C₁₆H₁₃O₄ • Cl

A trifluoroethylamide derivative of CDDO that enhances Nrf2 expression and signaling in various models of neurodegeneration; demonstrates anticancer activity against several neuroblastoma cell lines with IC₅₀s = 85-170 nM.

The E isomer of the pyrophosphonate form of HDMAPP; potently stimulates the synthesis of TNF-α by γδ-T lymphocytes with an IC₅₀ valueof 0.91 nM; also significantly increases the number of circulating γδ-T cells in vivo; stable both in solution and in vascular...

An Oct4-activating compound that activates expression through the Oct4 gene promoter; at 1 μM, enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts expressing Oct4 with Sox2, Klf4, and c-Myc.