Cayman Chemical

7-Piperazin-1-yl-thieno[2,3-c] pyridine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

An inhibitor of the catalytic PARP domain of TNKS1/2 that blocks canonical Wnt signaling with an IC₅₀ value of 790 nM; decreases β-catenin levels in colorectal cancer (CRC) cells, leading to down-regulation of Wnt target genes; inhibits the growth of CRC xenograft tumors in mice.

An amino-amide anesthetic that binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, preventing the generation of an action potential; inhibits the uptake of dopamine in striatal synaptosomes by 47% at 100 µM.

A target substrate for several of the histone modifying enzymes including lysine methyltransferases, arginine methyltransferases, acetyltransferases, and others.

Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet...

A fluorinated analog of AEA that serves as a substrate of FAAH (Km = 29 µM); used to perform n-FABS against FAAH to identify novel inhibitors.

An inhibitor of human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively; inhibits cooper-mediated oxidation of LDL by 91% at concentration of 2 µM.

Antigen: peptide from the extracellular loop 2 (EL2) region of human DAT Host: rabbit Cross Reactivity: (+) human, mouse, and rat DP1 Receptors Application(s): ICC and WB DAT is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies are widely used as markers for...

An adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively); induces smooth muscle contractions.

A fluorogenic substrate that can be cleaved by caspase-6 and related proteases including caspase-8.

A complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio; has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production; shows antiviral activity.

11β-PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11β-PGF2α by GC- or LC-MS.

6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM). It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs...

An antibiotic derived from rifamycin that targets most Gram-positive and Gram-negative bacteria; poorly absorbed after oral administration; effective in eliminating bacteria in the gastrointestinal system.

Inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells.

A platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death; cytotoxic to ovarian, lung, and other cancer cell lines (IC₅₀s = 14-200 μM).

A natural anthocyanin that has neuroprotective effects, reducing amyloid β-induced cytotoxicity in Neuro-2A cells; stimulates autophagy in U2OS cells.

A reversible, selective S-COMT inhibitor (IC₅₀s = 300 and 20 nM in rat liver and brain, respectively); reduces 3-OMD formation and elevates serum and brain L-DOPA, dopamine, and DOPAC levels at 3–30 mg/kg in rats when combined with L-DOPA/carbidopa.

An ATP-competitive inhibitor of PAK4, preventing the phosphorylation of the PAK4 substrate GEF-H1 (IC₅₀ = 1.3 nM) and blocking anchorage-independent growth of a panel of tumor cell lines (IC₅₀ = 4.7 nM); blocks the growth of multiple human tumor xenografts.

Molecular Formula: C₂₄H₂₇N₇O

A major metabolite of glycyrrhizin, a constituent of licorice that exhibits anti-ulcerative, anti-inflammatory, and immunomodulatory properties; at 100 mg/kg/day, reduces lipid peroxidation and increases antioxidant activity in diabetic rats; suppresses LPS-induced TNF-α production and...

2-(chloromethyl)-Pyrimidine (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.

A triptan that acts as an agonist of the serotonin (5-HT) receptors 5-HT1B and 5-HT1D (Kis = 2.2 and 0.92 nM, respectively); inhibits cAMP formation in blood vessels, resulting in vessel constriction.

NS-398 is a selective inhibitor of COX-2. The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 µM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 µM, respectively.