Cayman Chemical

Steroisomer of PGF1α with both C-9 and C-11 hydroxyls inverted.

A potent and selective inhibitor of TNKS1 and TNKS2 (IC₅₀s = 26 and 15 nM, respectively); blocks the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

Furegrelate is a potent inhibitor of thromboxane synthase with little effect on other enzymes essential for arachidonate metabolism. The IC₅₀ value is 15 nM for human platelet microsomal thromboxane synthase.

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human serum. Enterolactone and other ligans and...

Source: Recombinant C-terminal His-tagged protein expressed in E. coli MW: 47.9 kDa

Antigen: purified ovine COX-1 Host: mouse, clone CX111 Cross-Reactivity: (+) ovine, bovine, human, mouse, and rat COX-1, ovine COX-2 (50%), human COX-2 (~5%); (−) mouse COX-2 Application(s): FC and IF Isotype: IgG2b This product is derived by labeling the COX-1 monoclonal antibody (Catalog No....

A naturally occurring O-methylated phenolic acid that can be enzymatically degraded by some bacteria as a source of methane or methanol; inhibits aldose reductase (IC₅₀ = 213 µg/ml), proteasome activity, and cancer cell proliferation.

A racemic mixture of an epoxide biosynthesized in liver microsomes by CYP450.

8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no published studies on the pharmacological properties of 8-iso-16-cyclohexyl-tetranor PGE2.

This kit contains all reagents necessary for simple one-step purification of 8-isoprostane from most biological samples.

PGF1α alcohol is an analog of PGF1α with a primary alcohol replacing the C-1 carboxyl group. There are no published reports on the biological activity of this compound; however, the corresponding PGE1 analog (Item No. 13020) is a relatively selective EP3 and EP4 receptor ligand.

A slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of AP-A (glutamyl AP; IC₅₀ = 0.54 µg/ml) but not of AP-B (arginine AP); also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic...

An internal standard for the quantification of 5-PAHSA by GC- or LC-MS.

cAMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. cAMP is synthesized from ATP by membrane-bound adenylate cyclase...

A potent, stable, and selective agonist analog of AEA with a Ki value of 2.2 nM at the isolated rat CB1 receptor; 325 times more potent at the CB1 receptor compared with the CB2 receptor; induces hypothermia in mice with the same efficacy as AEA, in spite of its much higher affinity for the CB1...

A potent, selective inhibitor of PDE7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM; enhances the inhibitory effects of the PDE4 blocker rolipram on monocytes, lung macrophgaes, and CD8+ T-lymphocytes; promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B.

A synthetic intermediate useful for pharmaceutical synthesis.

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID), derived from naproxen but coupled to an H₂S-releasing moiety. At 30 µmol/kg in rats, it suppressed COX and gastric PGE₂ synthesis to the same level as naproxen but reduced COX-2 expression and accelerated recovery...

Thioarginine (hydrobromide) is a colorimetric substrate for arginase that provides the basis for continuous spectrophotometric measurement of enzyme activity. It exhibits Km and kcat values of 0.5 mM and 18,000 min−1, respectively, which are similar to physiological substrate arginine. The...

Antigen: mouse FP receptor amino acids 2-16 Host: rabbit Application(s): WB The FP receptor is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues. FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues, as well as, specialized cells...

A PPARα agonist used clinically to treat dyslipidemia and cardiovascular disease; exhibits EC50 values of 50 and 55 µM for mouse and human PPARα, respectively.

5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the...

An intermediary prodrug of fluorouracil, the pyrimidine analog that inhibits thymidylate synthase selectively in tumor cells, interfering with DNA synthesis; one of two intermediary metabolites formed during metabolic conversion of the chemotherapeutic prodrug, capecitabine, to fluorouracil.

An internal standard for the quantification of 17-phenyl trinor PGF2α by GC- or LC-MS.