Cayman Chemical

An internal standard for the quantification of GW 9662 by GC- or LC-MS.

A synthetic intermediate useful for pharmaceutical synthesis.

A partial receptor agonist of mGlu4, effective at 100 µM, with no activity at other mGlu receptor subtypes; induces apoptosis of T cells at 300-500 µM.

An antifungal antibiotic that selectively inhibits succinate dehydrogenase (complex II; IC50s = 12 and 3.7 nM in nematode and mammalian mitochondria, respectively, versus IC50s > 100 μM for inhibition of complex I and complex III enzymes); has cardioprotective effects against simulated...

A major hepatic metabolite of zearalenone that is a less potent agonist of estrogen receptors than the parent compound; has pronounced effects on uterotropic activity, sperm motility, and preimplantation embryonic development.

An inhibitor of PKB/Akt activity (IC50 = 10-50 µM) that inhibits insulin-stimulated glucose transport and intracellular protein translocation; inhibits additional serine/threonine kinases including PKA (IC50 = ~20 µM), p90 S6 (IC50 = ~50 µM), and MAP kinase (IC50 = ~35 µM).

A regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.

A selective, 2-OG competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively; increases the number of circulating reticulocytes and red blood cells, increases blood hemoglobin and hematocrit, and restores mean corpuscular volume and mean cell...

A stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle; stimulates PHD activity and increases HIF-1α turnover when used at 1 mM; competitively blocks succinate- or fumarate-mediated inhibition of PHD.

A potent inhibitor of EGFR-associated tyrosine kinase with an IC50 value of 0.012 µM that also inhibits pp60c-src(+) kinase and CamKII with IC50 values of 0.5 and 0.2 µM, respectively.

An imidazole antifungal; tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane; inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC₅₀ = 6.0 and 0.07 µM, respectively) in mammalian cells.

This assay offers the convenience of a fast assay (2 hour incubation; 1 hour development) while still achieving a detection limit (80% B/B0) of 10 pg/ml.

Inhibits BMP type I receptor-induced phosphorylation of SMAD1/5/8 (IC₅₀ = 4.9 nM); shows specificity for ALK1, 2, 3, and 6 (IC₅₀s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC₅₀s = 101 and 350 nM, respectively).

A potent, selective inhibitor of aldose reductase (IC₅₀ = 47 nM in vitro) used to improve the cytotoxic effects certain anticancer agents; inhibits PGF2α and PGE2 production in human endometrial cells (EC₅₀ = 10 μM).

An analog of SB-3CT that irreversibly inhibits MMP-2 (Ki = 2.4 µM); less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively); attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells.

A platinum-based antineoplastic agent that forms DNA adducts specifically in cancer cells, preventing DNA replication and transcription which induces apoptosis; cytotoxic in colon, ovarian, and lung cancer cell lines (IC₅₀s = 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively).

PGE2 p-benzamidophenyl ester is a crystalline derivative of PGE2. PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The...

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC₅₀ = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC₅₀s > 100 µM). It has...

Antigen: recombinant full-length human caspase-3 Host: mouse, clone 31A893 Cross Reactivity: (+) human caspase-3 Application(s): WB Caspase-3 cleaves the death substrate PARP to a specific 85 kDa form observed during apoptosis and is inhibitable by the CrmA protein. Other caspase-3 substrates...

A cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC₅₀ = 6-11 nM).

The most abundant sialic acid, found in bacteria as well as in eukaryotic cells; an essential component of human brain gangliosides and sialylated glycoproteins.

Antigen: human MBOAT1, C-terminal region Host: rabbit Species Reactivity: (+) human Application(s): WB

An uncompetitive inhibitor of Epac1 activity toward its effector Rap1 in vitro (IC₅₀ = 23 µM) and in cells; has no effect on PKA activity.

A potent skeletal muscle relaxant that also has uricosuric activity; recovery time from zoxazolamine-induced paralysis is used as a measure for change in CYP450 expression in mice.