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A benzylidene lactam compound that prevents the synthesis of inducible Hsps Hsp105, Hsp72, and Hsp40; at 100 μM, inhibits the development of thermotolerance in COLO 320 DM cells.
A minor, bioactive component of ginger with anti-inflammatory and anticancer properties; induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of...
An RXR ligand.
Ins(1,3)P2 can be dephosphorylated to Ins(1)P by inositol polyphosphate 3-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate polymorphonuclear leukocytes. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PC. Butanoyl PAF is a...
Dihomo-γ-linolenic acid (DGLA) is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Methyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary...
A potent inhibitor of ALK (IC50 = 1.9 nM) that induces concentration-dependent growth inhibition or cytotoxicity of ALK-positive cancer cells; inhibits ALK tyrosine phosphorylation in tumor xenografts in mice for more than 12 hours following single oral dosing at 30 mg/kg.
A synthetic intermediate useful for pharmaceutical synthesis.
One of the first indentified agonists of S1P2 demonstrating an EC50 value of 1 μM in a S1P reporter assay.
Antigen: peptide from human S1P5 within the region of amino acids 1-50 Host: rabbit Cross Reactivity: (+) canine, human, monkey, mouse, and rat S1PR5 Application(s): IHC and WB S1P5 is a receptor for the bioactive sphingolipid S1P as well as for LPA and gives diverse physiological effects on most...
Antigen: full length recombinant human HMGB1 Host: mouse, clone IMG19N15F4 Isotype: IgG1k Cross Reactivity: (+) human and mouse HMGB1 Applications: FC, IHC (paraffin-embedded tissue), and WB HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated...
A selective partial agonist of β3-adrenergic receptors (EC50s = 0.43, 580, and >10,000 nM for activation of β3-, β1-, and β2-adrenoceptors, respectively).
A potent and selective inhibitor of DGAT-1 (IC50 = 19 nM); has high oral bioavailability (100%) in rats with a moderate half-life of 6.8 hours; significantly blocks an increase in plasma triglyceride levels following a corn oil bolus in rats.
15(S)-15-methyl PGF2α is a metabolically stable analog of PGF2α. It is a potent uterine stimulant and abortifacient which can be administered intramuscularly to induce labor. It induces luteolysis and reduces serum progesterone concentrations when given as an intramuscular injection in...
A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 µM); used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.
TXA2 receptor agonist; causes platelet shape change (EC50 ~6 nM) and aggregation (EC50 ~97 nM).
Eicosapentaenoyl PAF C-16 can be formed by incorporation of EPA into lyso-PAF C-16, as has been demonstrated using neutrophils from monkeys and humans fed a diet enriched in fish oils. Eicosapentaenoyl PAF C-16 can serve as a substrate for PAF C-16 formation by the remodeling pathway.
A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).
A cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels (IC50 = 90 nM); reduces the size and number of renal cysts in a neonatal kidney organ culture model of polycystic kidney disease; increases VEGF-A production in cultured airway epithelial...
Antigen: hamster brain SAF (scrapie associated fibrils) Host: mouse, clone SAF 32 Isotype: IgG Application(s): ELISA, FC, IHC, and WB
A SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).
An internal standard for the quantification of PGE2 by GC- or LC-MS.
The deaminated/inactive derivative of PSI-6130, a selective inhibitor of HCV replication; can be triphosphorylated to form, RO 2433-TP, which inhibits RNA synthesis by HCV polymerase (IC50 = 1.19 µM).
A non-enzymatic, free radical peroxidation product of arachidonic acid; acts as a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively; approximately ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation...