Cayman Chemical

A cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations; disrupts the Warburg effect in cancer cells in culture and in vivo, suppressing the expression of glycolytic and lipogenic genes and reducing glycolytic metabolites and lipid production.

Major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE

A mycotoxin that inhibits the activity of HIV-1 integrases (IC₅₀ = 7-20 µM); reported to nonspecifically inhibit transport of mitochondrial metabolites, which can negatively affect mitochondrial function.

A natural agonist of the human sweet taste receptor and used as a flavorant; has diverse cellular effects at low doses, including antioxidant, anti-inflammatory, antimicrobial, and antiviral actions.

An irreversible inhibitor of mitochondrial Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain; used in animal models of Huntington’s disease and epilepsy.

An intermediate in the synthesis of the plant hormone ethylene; acts as a partial agonist at the glycine-binding site on NMDA receptors (EC₅₀ = 0.7-0.9 µM) and, in the presence of high levels of glutamate, as a competitive antagonist at the glutamate-binding site on NMDA receptors...

An analog of cyclopamine that inhibits the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM and dose dependently inhibits platelet aggregation in rabbits ex vivo; induces serotonin release and inhibits its re-uptake in the CNS.

Resveratrol (3,5,4'-trihydroxy-transstilbene), a polyphenol phytoalexin, possesses divers biochemical and physiological actions, including estrogenic, antiplatelet, and anti-inflammatory properties. Resveratrol upon an oral dose is almost completely conjugated to its glucuronide and sulfate...

A threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases; at 0.10-5 mM acts as a pro-oxidant inducing cell death in RINm5f pancreatic β-cells; used as a growth substrate for Pseudomonas.

An antitumor agent that binds to the human Smo receptor and inhibits Shh-induced Gli1 expression (IC₅₀ = ~2.4 nM in vitro).

A naturally-occurring macrocyclic lactone that is a potent insecticide; acts as an agonist of insect nicotinic acetylcholinesterase receptors (nAChRs), which differ both structurally and functionally from nAChRs in vertebrates.

A natural product that inhibits soybean LO-1 (IC₅₀ = 4.2 µM), cholesterol ester transfer protein (IC₅₀ = 19.4 µM), Grb2-Shc interaction (IC₅₀ = 22 µM), and antagonizes endothelin receptors (IC₅₀ = 114 and 152 µM for human ETA and...

A macrolide antibiotic that shows good bactericidal activity against MRSA.

A dihydroisocoumarin compound with a variety of biological activities including antibacterial, antimalarial, antifungal, and anticancer effects; inhibits proliferation of human breast cancer and melanoma cell lines with IC50 values > 200 μM.

PPARs are ligand-activated transcription factors belonging to the large superfamily of nuclear receptors. PPARα primarily activates genes encoding proteins involved in fatty acid oxidation, while PPARγ primarily activates genes directly involved in lipogenic pathway and insulin...

A metabolically stable methyl sulfonamide analog of 14(15)-EET; equipotent to 14(15)-EET in vascular agonist activity.

Mono-unsaturated fatty acids are components of the cellular membranes of autotrophic bacteria. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). cis-7-Hexadecenoic acid...

Felbamate is an antiepileptic drug that is effective against seizures in a variety of animal models. It has inhibitory effects at NMDA (Item No. 14581) and GABAA receptors and at voltage-gated channels. Adverse effects in humans, as well as drug interactions and significant side effects, has...

An SFA containing eleven carbons (C11:0) that is cytotoxic to certain filamentous fungi.

11-trans LTD4 is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging...

A fluorinated fucose analog that can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases.

(±)19(20)-DiHDPA is one of the major metabolites produced when DHA is incubated with NADPH-supplemented rat liver microsomes; formed by the slow metabolism of DHA by monkey seminal vesicles.

A synthetic intermediate useful for pharmaceutical synthesis.

A cell-permeant precursor for the high-affinity fluorescent calcium indicator quin-2 (Kd = 115 nM for calcium); ideal for monitoring low levels of calcium, as are found in resting cells; may be used to buffer intracellular calcium transients.