Cayman Chemical

The (S)-enantiomer of omeprazole, a selective inhibitor of the gastric H+/K+ ATPase that demonstrates increased bioavailability compared to omeprazole.

A potent and selective agonist for both LXRα and LXRβ (EC₅₀ = 50 nM).

A natural methylated trihydroxyflavone.

A selective inhibitor of SHIP2 (IC₅₀s = 0.62 and 0.34 µM for human and mouse, respectively; Ki = 0.44 µM for hSHIP2); dose-dependently increases insulin-induced phosphorylation of Akt and activates glucose metabolism.

An antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO with an IC₅₀ value of 2.2 µM; sensitizes cells to apoptotic stimuli.

(±)12-HpETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Item No. 90010) and consists of an equal mixture of the R and S isomers. Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (±)12-HETE (Item No....

N-3PyIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-3PyIA selectively inhibits human recombinant COX-2 with an IC₅₀ of 52 nM. It is about 1,300 times less potent as an inhibitor of ovine COX-1. However, N-3PyIA...

A full agonist of atrial and ileal muscarinic receptors with 15-fold reduced potency compared to the related nootropic, arecoline.

One of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa.

Immunogen: Peptide from the C-terminal region of rat lysoPLD Host: Rabbit Species Reactivity: (+) Human, mouse, and rat lysoPLD Application(s): ICC and WB lysoPLD was first discovered as the enzyme responsible for generating LPA from LPC. It was later revealed to be identical to an autocrine...

Cayman’s COX Fluorescent Activity Assay provides a convenient fluorescence-based method for detecting COX-1 or COX-2 activity in both crude (cell lysates/tissue homogenates) and purified enzyme preparations. The assay utilizes the peroxidase component of COXs. In this assay, the reaction...

(±)11-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 11(S)-HEPE and 11(R)-HEPE. The biological activity of (±)11-HEPE has not been clearly documented.

A selective agonist of human TLR7; enhances the immunosuppressive activity of Treg cells at 0.5 to 2 µg/ml.

WAY-208466 is a selective 5-HT₆ receptor agonist (EC₅₀ = 7.3 nM at the human 5-HT₆ receptor). It has been shown to increase cortical GABA levels in rat frontal cortex, producing anxiolytic-like effects in vivo.

A cell-permeable dye that is cleaved by intracellular esterases, leaving membrane-impermeant calcein, a fluorescent indicator with absorption and emission maxima of 494 and 517 nm, respectively.

A planar benzoic acid used as a non-immunoglobin protein scaffold for studies of protein-protein interactions; also has various industrial uses in synthesizing adhesive and coating materials, plastics engineering, and as a pharmaceutical intermediate.

4-(hydroxymercuri)Benzoic Acid(PHMB) is used to inhibit cysteine-protease and acts as a reversible thiol-specific blocker. While blocking the acylated ghrelin degradation, it allows the AcetylCholine Esterase AChE™ used in SPI-Bio EIA kits to work normally, in contrast to serine-protease...

DGLA is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as a...

Fluprostenol lactone diol is an intermediate used in the preparation of fluprostenol.

A potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC₅₀s = 0.74 and 0.80 nM, respectively); blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.

An analytical reference material categorized as a phytocannabinoid; has been found in strains of Cannabis; intended for research and forensic applications,,

Antigen: recombinant human LTA4 hydrolase Host: rabbit Cross-Reactivity: (+) human LTA4 hydrolase; other species not tested Application(s): WB Leukotriene A4 hydrolase is a bifunctional enzyme that converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase.

Molecular Formula C₁₇H₁₈FNO₂S Formula Weight 319.4

A 3-deoxyanthocyanidin.