Cayman Chemical

An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt...

A 24-carbon saturated (24:0) fatty acid that is synthesized during brain development and is found in cerebrosides.

LPA is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.{11049,13009} OMPT is a selective agonist of the LPA3 receptor. It exhibits EC50 values of 68 nM and >6.8 µM for calcium mobilization in LPA3 and...

A steroidal alkaloid that suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of iNOS and COX-2; functional inhibitor of acid sphingomyelinase; antibacterial against S. aureus variants; prevents skeletal muscle atrophy associated with fasting or spinal cord...

A fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics, such as studies of base stacking interactions and DNA base flipping; inhibits PKR.

A potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM; demonstrates anticancer, anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects.

3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). It selectively inhibits 5-lipoxygenase (IC₅₀ = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive...

Antigen: mouse COX-2 amino acids 570-598 (DPQPTKTATINASASHSRLDDINPTVLIK) Host: rabbit Cross-reactivity: (+) human, mouse, and rat COX-2; (−) COX-1 (all species) Applications: FC, IF, and WB

5,6,7,8-tetrahydro-2-Naphthoic Acid is a synthetic intermediate useful for pharmaceutical synthesis.

An M4 mAChR antagonist (pKi = 7.2 in chicken heart) that produces temporary mydriasis (pupil dilation; EC₅₀ = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC₅₀ = 25 µg/ml) when applied as eye drops; used to probe mAChR activity in a mouse model of fragile X...

Nicotinamide adenine dinucleotide (NAD) exists in an oxidized form, NAD+, as well as a reduced form, NADH. NAD, the main free form in cells, functions in modulating cellular redox status and by controlling signaling and transcriptional events, making it an important cofactor when investigating...

A cell-permeable analog of pifithrin-α that blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α; suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in...

A synthetic intermediate useful for pharmaceutical synthesis.

A dual agonist of PPARα and γ (IC₅₀s = 1 and 0.2 µM, respectively) that at 3 µM/kg/day for 3 weeks has been used to reduce insulin resistance in obese Zucker rats.

A selective, reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6, with optimal inhibition achieved at an MJ33 concentration of 3 mol%; blocks the degradation of DPPC in both whole lung and isolated alveolar type II epithelial cells.

A tetracyclic lantibiotic that demonstrates antiviral activity against HSV-1; also used as a probe for analyzing the transbilayer movement of phosphatidylethanolamine.

A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines; also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90 µM.

An antagonist of lipid A activation of TLR4 (IC₅₀ =1.68 μM), in a cell-based assay; significantly improves survival of mice given intraperitoneal LPS.

An inhibitor of SIRT2 (IC₅₀= 56.7 µM); induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.

A natural product from the bark of apple trees that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through competitive inhibition of SGLT1 and SGLT2; exhibits Ki values of 140 and 11 nM, respectively, at 37°C, for human SGLT1 and SGLT2, respectively.

A selective inhibitor of G9a and GLP methyltransferases that competitively inhibits binding of H3K9 substrates with a Ki = 3.7 nM; reduces H3K9 dimethylation levels in MDA-MB-231 and PANC-1 cells (IC₅₀s = 110 and 40 nM, respectively); displays improved pharmacokinetic properties relative...

11β-PGF2α-EA is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues. AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of...

A mechanism-based, irreversible inhibitor of CYP4A2, an enzyme that predominantly synthesizes 20-HETE in the mammalian kidney.

Enzymatically-derived PGF2α is an optically pure compound whereas PGF2α derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGF2α is the opposite enantiomer of PGF2α. This compound can only be generated via the isoprostane pathway of...