Cayman Chemical

A cyanoquinoline that irreversibly inhibits the receptor tyrosine kinases EGFR (IC₅₀ = 39 nM) and HER2 (IC₅₀ = 1.2 μM); disrupts Akt and MAPK pathways, inducing apoptosis and suppressing the growth of tumor cell lines.

6-hydroxy Chlorzoxazone is a CYP2E1 metabolite of chlorzoxazone.

A specific, cell permeable inhibitor of Cdc42 (IC₅₀ = 2 μM); has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2.

An orally available, non-peptidic inhibitor of MMP-2, MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively); active in various animal models of tumor metastasis and has been used in a phase III clinical trial in pancreatic, SCLC, NSCLC, and ovarian cancer patients.

An anti-leukemia agent with apoptosis-promoting and chemosensitizing properties; inhibits Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.

Glycerol is the backbone of triglycerides and an important intermediate in energy metabolism being involved in both oxidative and synthetic processes. The circulating levels of glycerol and free fatty acids are considered to reflect lipolysis and are therefore useful parameters to evaluate in...

A selective IGF-1R inhibitor (IC₅₀ = 0.17 µM); inhibits tumor proliferation both in vitro and in a mouse model of multiple myeloma.

An agonist for mCAR (EC₅₀ = 20 nM) that is effective for the mouse receptor but not for human or rat CAR receptors; potently induces cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins.

Formal Name: N-?[[(4-?aminophenyl)?amino]?thioxomethyl]?-?4-?(1,?1-?dimethylethyl)?-benzamide CAS Number: 1011301-27-1 Molecular Formula: C₁₈H₂₁N₃OS

Pyrimidin-4-yl-Methanol is a synthetic intermediate useful for pharmaceutical synthesis.

A potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM); can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.

A microbial metabolite isolated from Streptomyces that is widely used as a selective inhibitor of the 20S proteasome.

An isomer of 17-phenyl trinor PGF2α ethyl amide, characterized by an inverted (β) hydroxyl group at C-15.

A certified reference material categorized as a phytocannabinoid; a bis-homolog of cannabidiol; has been found in certain strains of Cannabis; intended for research and forensic applications

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing T. brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less...

A phenothiazine compound with anti-adrenergic (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C receptors, respectively) and antidopaminergic (Kd = 0.96 nM for the dopamine D2-like receptor) actions typical of antipsychotic agents; also antagonizes calmodulin and...

Butaprost is a structural analog of PGE2 with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Serious confusion as to the structure of Butaprost was...

A potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity; activates sirtuins and, in C. elegans, extends lifespan.

Ins(1,4,5)P3 is a second messenger produced in cells by PLC mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels...

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser40 of rat TH Host: rabbit Cross-reactivity: (+) mammalian and non-mammalian species Applications: WB, IF (frozen sections), and IHC (frozen sections)

A cyclic LPA analog that contains the 18:1 fatty acid, oleate, at the sn-1 position; at 25 μM, inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers without affecting proliferation; at 0.1-1.0 μM, significantly inhibits autotaxin and antagonizes LPA1 (IC50 = 836...

A form of the sugar Neu5Ac O-linked with the nucleotide CMP; serves as the substrate for sialyltransferases, which transfer Neu5Ac from CMP-sialic acid to various acceptor substrates, most commonly at terminal positions of the oligosaccharide component of glycoproteins or glycolipids.

An analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide analogous to Bimatoprost.

A cell permeable analog of cAMP that activates PKA with a Ka value of 0.05 μM; more stable to hydrolysis and has increased membrane permeability compared to unmodified cAMP.