Cayman Chemical

An alkaloid amide from species of the genus Piper, a plant used in traditional medicine that demonstrates antifungal, anticancer, antihyperlipidemic, and anti-inflammatory properties.

A synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM); disrupts binding of BET proteins with acetylated histones, suppressing the expression of specific inflammatory genes involved in sepsis and endotoxic shock.

A potent inhibitor of PKA signaling that acts through competitive inhibition of ATP (Ki = 60 nM).

A phytoestrogen that activates ERα and ERβ (EC50s = 320 and 680 nM, respectively); stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats.

A ureido-sulfonamide inhibitor of carbonic anhydrases IX and CAXII (Kis = 45.1 and 4.5 nM, respectively) that binds only under hypoxic conditions, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

A selective SIP1 agonist (EC₅₀ = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC₅₀ = 46 nM); induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively, at 50 nM.

Antigen: peptide from the C-terminal region of human GPR41 Host: rabbit Cross Reactivity: (+) human GPR41 Application(s): FC, IF, and WB

Source: Purified from human plasma, citrullinated with human recombinant PAD2 MW: α chain isoform 1 (95 kDa), α chain isoform 2 (69.8 kDa), β chain (55.9k Da), and,isoform γ-B chain (51.5 kDa)

Source: Recombinant GST-tagged protein expressed in E. coli Mr: 73.4 kDa The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.

A competitive inhibitor of 15-hydroxy PGDH; acts as an agonist on most EP receptor subtypes (Kd d~ 1 nM for isolated EP2 receptors); preserves the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.

An active site-directed agent that inhibits serine proteinases with trypsin-like activity; may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes.

A quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml; also blocks neuronal uptake of dopamine in mammals...

The HIF (hypoxia-inducible factor) transcription factor is a member of the basic-helix-loop-helix (bHLH) family of transcription factors and plays an important role in maintaining cellular oxygen homeostasis. HIF-1α has emerged as an important drug target in breast and prostate cancer,...

A nucleoside analog with antiviral activity, inhibiting thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM).

Sodium chloride stock solution contains filtered sodium chloride (5 M). It is ready to use as supplied.

A potent synthetic agonist of GPR55 (EC₅₀ = 0.26 µM); does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC₅₀s = 21.8 and 15.1 µM, respectively).

A small molecule inducer of adult neural stem cell differentiation; 2.5-20 µM triggers neurogenesis and blocks gliogenesis in HCN cells through a neurotransmitter-mediated calcium signal and myocyte-enhancer factor 2-dependent gene expression pathway.

A DHCR7 inhibitor that prevents cholesterol biosynthesis and Hedgehog signaling; used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models.

Source: Recombinant N-terminal His-tagged protein expressed in E. coli MW: 40.48 kDa Annexin A1 is an endogenous mediator of inflammation, promoting resolution in a number of ways. Normally expressed in intracellular compartments, it is drawn to the cell membrane and both induced and externalized by...

A hybrid molecule of an H2S donor and the NSAID indomethacin that does not cause gastric damage or promote leukocyte adherence to vascular endothelium.

A selective ligand of RORγ (IC50 = 1 μM); does not bind RORα, LXR, or FXR; acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression and suppressing differentiation of TH17 cells; stimulates T regulatory development.

A reversible, cell-permeable inhibitor of VEGFR2’s kinase activity (IC₅₀ = 70 nM); less potently inhibits PDGFRβ (IC₅₀ = 920 nM); blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC₅₀s = 110 nM and 2...

A well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM) which interferes with glycolysis; through ATP depletion, synergizes with chemotherapy drugs, like cisplatin, in killing cancer cells (IC50 = 0.5 mM); reduces cardiovascular oxidative injury...

A nine isoprenyl group-containing member of the mitochondrial ubiquinone family thought to be necessary for the biosynthesis of CoQ10 in humans; enables electron transport through the mitochondrial respiratory chain and demonstrates antioxidant functions in mice and C. elegans.