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A natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes; also a weak inhibitor of the related zinc metalloprotease ECE (Ki = 3.5 µM); has little or no effect on a variety of other proteases.
Antigen: human nNOS amino acids 1422-1433 Host: rabbit Cross Reactivity: (+) rat and human nNOS; (−) iNOS and eNOS Application(s): ICC, IHC, IP, and WB NOS catalyzes the oxidation of arginine to nitric oxide and citrulline. nNOS is a soluble enzyme found in brain, the peripheral nervous system...
The Cayman Chemical (5z)-7-[(1r,2r,3s,5s)-2-[[(5-hydroxybenzo[b]thien-3-yl)carbonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-3-yl]-5-heptenoic acid is suitable for use in research facilities and chemical laboratories to conduct wide range of experiments. It is available in sturdy bottle that endures...
L(+)-Lactate is the major stereoisomer of lactate formed in human intermediary metabolism. The lactate to pyruvate ratio reflects the redox state of the cell and describes the balance between NAD+ and NADH, which is dependent on the interconversion of lactate and pyruvate via lactate dehydrogenase...
An inhibitor of dihydropyrimidine dehydrogenase, the rate limiting enzyme for the catabolism of pyrimidines; administered concomitantly with 5-fluorouracil in a chemotherapy regimen to block 5-fluorouracil degradation; inhibits homologous recombination in the repair of DNA double strand breaks.
A cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM); poorly inhibits PI3K (IC50 = 13 µM) and is inactive against ATM, ATR, and PARP-1.
Steatosis, also known as fatty liver, is a pathological process characterized by abnormal accumulation of lipids within cells. Cayman’s Steatosis Colorimetric Assay provides a convenient tool for evaluating the steatosis risk of drug candidates. In this assay, Oil Red O is used to stain...
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes...
A fluorescent calcium indicator that displays a very low affinity for calcium (Kd = 320 µM).
Immunogen: peptide from the C-terminal region of mouse COX-2 Host: rabbit Cross-reactivity: (-) COX-1 (all species) Species reactivity: (+) human, guinea pig, monkey, mouse, ovine, rabbit, and rat COX-2 Applications: WB and IHC
An intermediate formed in the β-oxidation of palmitic acid.
A homoserine lactone member that possesses a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in P. aeruginosa strains.
Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Tyr1252 of the human NMDA Receptor NR2B Subunit Host: rabbit Cross Reactivity: (+) human and rat NMDA receptor; expected to react with bovine, canine, chicken, mouse, non-human primates, and zebrafish NMDA receptor...
Source: Active recombinant N-terminal His-tagged protein expressed in Sf21 cells Mr: 43.7 kDa PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets. Non-histone targets of PRMT6...
An analog of the PKC-activating second messenger DAG.
A conjugated PUFA that induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM); increases the production of ROS, leading to oxidative stress that contributes to cytotoxicity.
A trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit; inhibits spontaneous IgG, IgM, and IgA production by human peripheral blood mononuclear cells; putative host cell receptor for the Merkel cell polyomavirus.
Inhibits CKII (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM); inhibits elongation during RNA polymerase II transcription; triggers p53-dependent apoptosis of human colon adenocarcinoma cells; inhibits trans-activated transcription...
Antigen: synthetic peptide from human AROS within the region of amino acids 1-50 Host: rabbit Cross-Reactivity: (+) human AROS Application(s): WB AROS interacts with extraribosomal protein RPS19, playing a role in the signaling pathways that regulate rRNA transcription.
A polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.
The mitochondrial F1FO ATP synthase, commonly referred to as complex V, is a multi-subunit protein that utilizes energy in the form of a proton gradient generated by the electron transport chain, to phosphorylate ADP to form ATP in the presence of Pi. This mechanism, referred to as oxidative...
A selective, SAM-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM); inhibits global H3K27me3 levels, inhibiting the proliferation of EZH2 mutant DLBCL cell lines (IC50...
An irreversible inhibitor of mitochondrial complex I that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme; inhibits photosystem II in plants; suppresses the up-regulation of GRP78 in glucose-deprived, etoposide-resistant HT-29 cells,...
A dithiol used, both in vitro and in vivo, to promote the correct folding of proteins that require disulfide bonds for functionality.