Cayman Chemical

An synthetic DAG that inhibits PKC.

A selective inhibitor of CaMKII, competitively blocking CaM binding to the kinase (Ki = 370 nM); inhibits histamine-induced aminopyrine uptake in parietal cells (IC₅₀ = 300 nM).

One of several novel taurine-conjugated fatty acids that act as a FAAH substrate and may activate TRPV1 and TRPV4.

A high-affinity ligand for retinoid X receptors (RXRs)(EC50 = 28, 25, and 20 nM for RXRα, β, and γ, respectively); inhibits cell cycle progression, induces apoptosis, and blocks angiogenesis and metastasis; stimulates clearance of soluble Aβ, reduces plaque area, and reverses...

A mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.

A main component of the outer layer of the epicuticle of human hair that is used as an additive to hair cosmetics due to its desirable conditioning effects.

A natural anthocyanin and potent antioxidant.

An agonist of insect nicotinic acetylcholinesterase receptors that demonstrates insecticidal activity against H. virescens larvae (tobacco budworm) with an LD50 value of 0.8 ppm.

A potent DOT1L inhibitor (IC₅₀ = 400 pM) that selectively kills (MLL) cells in vitro and prolongs survival in an MLL xenograft mouse model; accelerates the reprogramming of somatic cells into induced pluripotent stem cells.

Ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke; blocks autophagy, reduces inflammation, and inhibits apoptosis in isolated neurons and in brains; induces apoptosis in colon cancer cells.

A histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine; also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves.

A minor alkaloid produced in plants of the Solanaceae family, including tobacco; detection in urine is used as an indicator of tobacco use; diminishes Aβ production, reduces the transcription and protein levels of β-secretase, and dose dependently inhibits NF-κB activation.

An inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM); can be used with cells in culture and in animals.

A fluorescent probe for Aβ.

α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM.

A water soluble, cyclic octapeptide which acts as a receptor antagonist that is selective for the µ opioid receptor (IC₅₀ = 3.5 nM) over the δ receptor (IC₅₀ = 4,500 nM); a poor antagonist of the somatostatin receptor (IC₅₀ = 14.3 μM).

A methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 µM in vitro); potently blocks the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC₅₀s = 0.37 and 0.044 µM, respectively).

A non-selective bromodomain inhibitor that at 1 µM has been shown to accelerate FRAP recovery of BRD4 and CREBBP bromodomains in HeLa cells.

The most abundant isoprostane product formed during lipid peroxidation; detected after CCl4-induced oxidative damage to hepatic tissue and has been found elevated in the urine, blood, and CSF of patients with Alzheimer’s disease.

A potent anticarcinogen that effectively induces phase I and II detoxifying enzymes and has been linked to activating the transcription factors Nrf2 and CAR.

A fluoropyrimidine carbamate which acts as a prodrug, being enzymatically converted to 5-fluorouracil by enzymes concentrated in the liver and in cancer tissue.

A reversible inhibitor of Lp-PLA2 (IC₅₀ = 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans.

A third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls; increases EAAT-2 pump expression in the CNS and reduces glutamatergic toxicity in both in vitro and in vivo models.