Cayman Chemical

A lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α.

Selective, nonpeptide antagonist of the CRH-R1 (Ki = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress.

A selective ERRβ/γ receptor agonist (EC₅₀ = 130 nM); used to potentiate ERRγ-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines.

A benzoquinone ansamycin antibiotic that acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and Hsp90; inhibits Bcr-Abl with an IC₅₀ value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB; binds Hsp90 and destabilizes client proteins,...

15(S)-15-methyl PGE1 is a metabolically stable synthetic analog of PGE1. In sharp contrast to the bronchodilatory effects of PGE1, 15(S)-15-methyl PGE1 is a weak constrictor of human respiratory tract smooth muscle.

A more lipid-soluble form of EPA.

A folate analog antimetabolite that inhibits GART preventing de novo purine synthesis; inhibits DNA synthesis, arrests cells in the S phase of the cell cycle, and inhibits tumor cell proliferation.

12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus. The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

A small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria; appears later than shorter chain AHLs in developing biofilms and, like other long chain AHLs, stimulates bacterial growth; alters proteolytic activity...

An antagonist of CXCR4, blocking CXCR4-mediated HIV infection with an IC50 value of 19.3 nM; at 100 μg/ml, inhibits CXCL12-induced phosphorylation of p42/44 MAPK and STAT3; activates CXCR7 (EC50 = 350 nM), resulting in the recruitment of β-arrestin and Erk ½ phosphorylation.

The PGE2 Quant-PAK has been designed for the convenient, precise quantification of PGE2 by GC- or LC-MS. It includes a 50 µg vial of PGE2-d4 and a precisely weighed vial of unlabeled PGE2, with the precise weight (2-4 mg) indicated on the vial. This unlabeled PGE2 can be used to quantify the...

A selective allosteric inhibitor of Bcr-Abl (IC₅₀s = 4.52, 0.38, and 0.93 µM against Bcr-Abl mutants G250E, E255V, and M351T, respectively); displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse...

A potent inhibitor of GSK-3β (IC₅₀ = 22 nM), preventing tau phosphorylation both in vitro and in vivo.

A corrinoid vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism; serves as a cofactor in isomerase-, methyltransferase-, and dehalogenase-catalyzed reactions,...

A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

A glycylcycline antibiotic with a broad spectrum of activity against many Gram-positive, Gram-negative, and anaerobic organisms, including many multidrug-resistant strains.

A synthetic intermediate useful for pharmaceutical synthesis.

A steroidal antibiotic that inhibits the translocation function of the elongation factor EF-G (IC₅₀ = ~10–200 μM) during bacterial protein synthesis; inhibits the replication of gram-positive bacteria including Staphylococcus, Streptococcus, and Corynebacterium species.

A cyclododecadepsipeptide potassium-selective ionophore antibotic; induces apoptosis in several cell tyes, including CHO cells, by stimulating potassium efflux.

A butaprost analog with a 5,6-double bond and without the methyl ester.

17-phenyl trinor PGA2 is a synthetic prostaglandin analog designed for increased half-life and greater potency. There are no published reports of the biological activity of 17-phenyl trinor PGA2 in the literature at this time.

A selective inhibitor of MEK1 and MEK2 (IC₅₀s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2; rapidly passes the blood-brain barrier and has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior.

A selective CB2 receptor ligand with Ki values of 0.47 and 0.081 µM for human CB1 and CB2 receptors, respectively.