Cayman Chemical

A certified reference material categorized as a phytocannabinoid; a precursor in the biosynthesis of tetrahydrocannabinolic acid, cannabidiolic acid, and cannabichromenic acid; intended for research and forensic applications

Source: recombinant N-terminal His-tagged protein purified from E. coli Mr: 46.4 kDa

Antigen: human lysophosphatidic acid 1 (LPA1) amino acids 342-359 Host: rabbit Cross Reactivity: (+) bovine, human, mouse, ovine, and rat LPA1 Application(s): ICC and WB LPA1 is a GPCR that couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including...

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents. Ins(1,3,4,5,6)P5 is one of the many inositol phosphate isomers that act as small, soluble second messengers in the...

A major metabolite of PGD2 found in human and mouse urine at levels of approximately 1.5 and 8.1 ng/mg creatinine, respectively.

An analog of curcumin obtained by methylation of both free phenolic groups in the parent compound; 30-fold increase in potency was observed in the growth suppression of HCT116 tumor cells following this modification.

A benzoic acid derivative that inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC₅₀ value of 0.67 µM; enhances the renal excretion of urate while reducing the elimination of many medications; acts as an agonist of...

Reactive oxygen species (ROS) play important roles in the initiation and progression of many disease processes. Most fluorescent probes for ROS detection, such as 2,7-dichlorofluorescein (DCFH), function by an oxidative mechanism and are useful for total oxidant detection but are not selective for...

A potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively.

A specific PKC inhibitor (IC₅₀ = 50 nM versus an IC₅₀ > 50 μM for PKA) whose activation depends on exposure to light; also inhibits phospholipase D1 and D2 (IC₅₀s = 100 nM); demonstrates antitumor activity.

A bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.

A synthetic progesterone analog (i.e., a progestin) and the biologically active compnent of norgestrel, which is a racemic mixture.

A CYP450 ω-oxidation metabolite of PGE2 that preceeds β-oxidation and the loss of up to four carbons from the lower side chain of PGE2.

Source: Recombinant N-terminal GST-tagged enzyme expressed in E. coli Mr: 60.6 kDa (GST-tag); 26 kDa (native) SIRT5 is located in the mitochondrial matrix and its functions are largely still being elucidated, however a few promising substrates have been studied. SIRT5 has been shown to deacetylate...

A cell-permeable, cGMP analog that activates cGMP-dependent protein kinase.

PAD2 is a guanidino-modifying enzyme that catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. This enzyme has been implicated in several diseases, including rheumatoid arthritis (RA), retinal degeneration, and certain cancers. PAD2 has been shown to...

Myristic acid is a saturated fatty acid commonly found in animal and vegetable fats that is frequently used in cosmetics, soaps, perfumes, and flavorings. It increases LDL cholesterol making it one of the most hypercholesterolemic of the saturated fatty acids. Myristic acid ethyl ester is a more...

A butyrophenone that acts as an antagonist at dopamine receptors (Kis = 0.25 and 0.84 nM at human D2 and D4); less potently inhibits the human voltage-gated potassium channel (IC₅₀ = 32 nM).

An orally available HDAC inhibitor that selectively targets HDAC1 and 2 (IC₅₀s = 0.15 and 0.29 µM, respectively), less potently inhibits HDAC3 and 11 (IC₅₀s = 1.66 and 0.59 µM, respectively); induces hyperacetylation of histones, causes cell cycle blockade, and...

A selective FXR agonist (EC₅₀ = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (EC₅₀ = 80 nM).

A type B trichothecene mycotoxin.

A centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat) that also inhibits dopamine uptake through the dopamine transporter (Ki = 160 nM); used in the management of Parkinson’s disease symptoms to address involuntary tremor and dystonia.

Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED₅₀ = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils...