Cayman Chemical

A benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC₅₀ = 0.09 and 0.9 µM, respectively); dose-dependently blocks PGE2 synthesis in isolated cells and whole blood treated with LPS or IL-1β; dose-dependently reduces PGE2 synthesis and cell recruitment...

A selective inhibitor of TGF-β type 1 receptor (TGFBR1 or ALK5; IC₅₀ = 18 nM); inhibits the expression of collagen type I in cells (IC₅₀ = 93 nM) and in mice when given orally at 10 mg/kg once a day; reduces typical features of fibrosis.

A homolog of EPEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

An anti-epileptic drug that inhibits the synaptosomal uptake of GABA, increasing the activation of GABAA receptors; inhibits CYP3A4, CYP1A2, and CYP2C19; inhibits LDH, blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH isoforms 1 and 5 at 500 µM.

A 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA supplied exogenously to resident peritoneal mouse macrophages activated with zymosan A; reduces infiltration of neutrophils into the mouse peritoneum and increases phagocytosis of FITC-labeled zymosan A by macrophages.

An ionophore antibiotic used in veterinary practice as a coccidiostat for gastrointestinal parasites; inhibits NF-κB signaling via inhibition of IκBα phosphorylation (IC₅₀ = 3.2 µM) and stimulates TRAIL-mediated apoptosis in glioma cells via ER stress.

A potent, selective inhibitor of Stearoyl-CoA desaturase 1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.

A nonpeptidic antagonist of CCK1 (IC₅₀ = 50 nM) that is 60-fold less effective at CCK2 (IC₅₀ = 3 µM); blocks CCK-mediated gut muscle contraction, pancreatic growth, and pancreatic secretion; commonly used to study the roles of CCK1 in tissues and in animals.

A synthetic PGA1 analog with structural features similar to 15-deoxy-Δ12,14-PGJ2, a ligand for PPARγ.

A cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC50 = 0.5 μM). It less effectively inhibits p110γ and p110β (IC50 = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases.

A selective dual MEK/Aurora kinase inhibitor (IC₅₀s = 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively); inhibits the growth and survival of both treatment-naïve and drug-resistant melanoma both in vitro and in vivo,...

This assay has been developed for researchers that do not have experience performing ELISAs. It can be used as a practice tool allowing you to become comfortable with running Cayman ELISAs. This kit contains enough reagents to run at least four complete standard curves.

Antigen: human FABP4 amino acids 103-118 Host: rabbit Cross Reactivity: (+) human, mouse, and rat FABP4; (−) FABP3 and FABP5 Application(s): ICC and WB

A natural chemical found in fresh ginger that activates TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM).

The tumor suppressor protein p53 plays a crucial role in coordinating cellular responses to genotoxic stress and holds many important clinical implications in the treatment of cancer. Cayman’s p53 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific...

A potent, orally bioavailable, ATP-competitive small-molecule dual inhibitor of c-MET (IC₅₀ = 8 nM) and ALK (IC₅₀ = 20 nM) receptor tyrosine kinases; shows antitumor efficacy in multiple tumor models implanted in athymic mice that express activated c-MET or ALK fusion proteins...

A potent inhibitor of Eg5, both in vitro and in cells (IC₅₀s = 127 and 190 nM, respectively); blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells.

7-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis.

A selective Mcl-1 inhibitor (Ki = 490 nM) that disrupts the heterodimerization of Mcl-1/Bax and Mcl-1/Bak; induces apoptosis of various pancreatic cancer cell lines (IC₅₀s = 3.4-16.1 μM); demonstrates antitumor activity in a BxPC-3 xenograft mouse model.

A potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM).

An inhibitor of PD-1/PD-L1 interaction.

The active metabolite of allopurinol, an inhibitor of xanthine oxidoreductase.

A synthetic intermediate useful for pharmaceutical synthesis.

L-Arginine serves as a common substrate for both NOS and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine....