A selective Mcl-1 inhibitor (Ki = 490 nM) that disrupts the heterodimerization of Mcl-1/Bax and Mcl-1/Bak; induces apoptosis of various pancreatic cancer cell lines (IC50s = 3.4-16.1 μM); demonstrates antitumor activity in a BxPC-3 xenograft mouse model.