Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.
Bioactivity Assay:TF-1 cell proliferation; ED50 =20 ng/mL; Bioactivity =5.0 x 10^4 units/mg