Macrophage inflammatory protein-1 beta (MIP-1 ß), also known as CCL4, is produced by macrophages and functions as a mitogen-inducible cytokine. MIP-1 ß signals through the chemokine receptor CCR5 to chemoattract immune cells. MIP-1 ß induces inflammatory responses, including neutrophil superoxide production. The MIP-1 ß and MIP-1 a heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).
Bioactivity Assay:THP-1 chemotaxis; ED50 =100 ng/mL; Bioactivity =NA