Macrophage inflammatory protein-1 alpha (MIP-1 a), also known as CCL3, is a cytokine produced by macrophages. MIP-1 a binds the chemokine receptors CCR1, CCR4, and CCR5 to induce inflammatory responses, including the recruitment of granulocytes and neutrophil superoxide production. The MIP-1 a and MIP-1 ß heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).
Bioactivity Assay:THP-1 chemotaxis; ED50 =100 ng/mL; Bioactivity =NA