Interferon gamma (IFN-?) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-? is produced by T cells and natural killer cells following antigen-specific activation. IFN-? binds IFN-? receptors (IFN-? R1 and IFN-? R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-?-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Mouse IFN-? is not cross-reactive with human IFN-?.
Bioactivity Assay:Viral CPE assay using EMC virus on L929 cells; ED50 =1ng/mL; Bioactivity =1.0 x 10^6 units/mg