Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.
Bioactivity Assay: Ability to induce bioluminescence in engineered RANKL bioassay cells ; ED50 =50 ng/mL; Bioactivity =2.0 x 10^4 units/mg