Neurotrophin-4 (NT-4) is an important member of the nerve growth factor (NGF) family of proteins. Neurotrophins undergo paracrine and autocrine signaling to control neuronal survival, neuronal differentiation, and dendrite outgrowth. NT-4 is expressed ubiquitously and signals through the TrkB receptor tryrosine kinase.
Bioactivity Assay:Proliferation of a neuroblastoma cell line stably expressing TrkB (BR6); ED50 =20 ng/mL; Bioactivity =5.0 x 10^4 units/mg