Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
Bioactivity Assay:Inhibition of human IL-1 alpha induced proliferation of D10.G4.1 cells; ED50 =50 ng/mL; Bioactivity =2.0 x 10^4 units/mg