Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Ra receptor to activate JAK downstream signaling. Human IL-11 shows activity on murine cells.
Bioactivity Assay:TF-1 Cell Proliferation; ED50 =10 ng/mL; Bioactivity =1.0 x 10^5 units/mg