Insulin-like growth factor II (IGF-II) is an important fetal growth hormone made by theca cells during gestation. IGF-II engages the IGF-I receptor (IGF1R) to mediate embryonic growth. IGF-II also binds the sink IGF-II receptor (IGF2R) leading to IGF-II degradation.
Bioactivity Assay:rh IGF-II activity is tested in human breast cancer cell line MCF-7; ED50 =6 ng/mL; Bioactivity =1.7 x 10^5 units/mg