Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.
Bioactivity Assay:C6 proliferation; ED50 =3 ug/mL; Bioactivity =3.3 x 10^2 units/mg