Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) and transforming growth factor beta (TGF-ß) families and functions to regulate cell proliferation and differentiation in embryonic and adult tissues. GDF-5 is expressed in the central nervous system and promotes the survival of dopaminergic neurons in animal models of Parkinson's disease. GDF-5 is also important during chondrogenesis and chondrocyte differentiation.
Bioactivity Assay:Alkaline phosphatase activity in ATDC5 cells; ED50 =1200 ng/mL; Bioactivity =8.3 x 10^2 units/mg