Epidermal growth factor (EGF) is a growth factor that stimulates the proliferation, differentiation, and survival of epithelial and epidermal cells. EGF contains three intramolecular disulfide bonds and binds in high affinity to the epidermal growth factor receptor (EGFR). EGF is overexpressed in multiple tumor cell lines and promotes resistance to chemotherapy and radiation treatments.
Bioactivity Assay:BALB/c 3T3 cell proliferation; ED50 =0.1 ng/mL; Bioactivity =1.0 x 10^7 units/mg