Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival. BDNF expression in the hippocampus is essential for long-term memory storage and learning. Human, mouse, rat, and pig BDNF are cross-reactive.
Bioactivity Assay:Proliferation of a neuroblastoma cell line stably expressing TrkB (BR6); ED50 =40 ng/mL; Bioactivity =2.5 x 10^4 units/mg