Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).
Bioactivity Assay:Proliferation of a neuroblastoma cell line stably expressing TrkB (BR6); ED50 =20 ng/mL; Bioactivity =5.0 x 10^4 units/mg