PRIME-XV NK Cell CDM is the first commercially-available, chemically defined, and animal component-free medium for the ex vivo expansion of NK and NKT cells. Designed for use in NK and NKT cell-based immunotherapy research and translational applications, this advanced formulation delivers growth while maintaining NK and NKT cell functionality and potency - without the need for serum supplementation. Chemically defined, animal component-free natural killer cell culture medium
- Supports robust cell expansion and viability in heterogeneous PBMC culture enriched for CD56+ cells
- Supports expansion of NK cells when supplemented with IL-2, IL-12, IL-18, and IL-21
- Supports NKT cell expansion when supplemented with IL-2
- Maintains high NK and NKT cytotoxic capability Designed and manufactured to facilitate transfer from research to clinic. Supported by robust raw material controls and supply chain management
- FDA, Federal, and State registered - cGMP-compliant manufacture
- EN ISO 13485:2016 certified
- MDSAP certified
- Extensive QC testing including functionality, sterility (USP <71>), endotoxin (USP <85>), and mycoplasma (USP <63>)
- Drug Master Files (DMFs) filed with the FDA – available upon request
Chemically defined, animal component-free medium for natural killer (NK) and NKT cell expansion optimized to deliver cell growth while maintaining NK and NKT cell functionality and potency., 1 L, 18 month shelf life