PG-011 is composed of a cyclic peptide that has binding affinity for FGFR1c and exhibits agonist activity toward FGFR1c.
We conducted a comparison of the cell proliferation activity of PG-011 and FGF2 using bone marrow-derived human MSCs (mesenchymal stem cells). The results showed that PG-011 exhibited comparable cell proliferation activity to FGF2. When compared on a mass concentration basis (ng/mL), PG-011 demonstrated equivalent activity to FGF2 at approximately one-third the concentration.
We evaluated the proliferation and pluripotency maintenance abilities of iPSCs using PG-011. The culture media were supplemented with either FGF2 (100 ng/mL, approx. 5.9 nM) or an equivalent molar concentration of PG-011 (approx. 30 ng/mL). The results confirmed that, for all three cell lines evaluated, PG-011 and FGF2 showed similar rates of positive pluripotency markers. This confirms that PG-011 has equivalent iPSC pluripotency maintenance capability to FGF2.
Provided as lyophilized powder
Purity: greater than or equal to 95% (HPLC)
MW (Da): 5127.81 (acetate)
https://peptigrowth.com/en/products/pg-011/
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