SCF is a multipotent factor which affects cells of the myeloid, erythroid, mast, and lymphoid lineages. • Exists both as a membrane-bound and soluble form • Expressed by fibroblasts and endothelial cells promoting proliferation, migration, survival, and differentiation in hematopoietic progenitors, melanocytes, and germ cells • Promotes mast cell secretory function, chemotaxis, and adhesion • Enhances secretion of mediators in response to IgE-dependent activation The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Bioactivity Assay:Proliferation of TF-1 ; ED50 =15 ng/mL; Bioactivity =1.0x10^3 IU/µg