IL-4 is an immunomodulatory cytokine that stimulates B cell proliferation and activates eosinophils, basophils, and mast cells. • Induces vascular cell adhesion molecule (VCAM)-1 expression on endothelial cells and involved in collagen production by fibroblasts • Plays a key role in promotion of Th2 differentiation from naïve helper T cells • Defines the Th2 phenotype of lymphocytes • Regulates cell proliferation, apoptosis, and expression of numerous genes in various cell types The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance
Bioactivity Assay:TF-1 cell proliferation; ED50 =0.25 ng/mL; Bioactivity =1.4x10^4 IU/µg