IL-15 is a widely expressed proinflammatory cytokine that is structurally and functionally related to IL-2. • Signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors • Regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function • Dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases • Combines with other common ? chain cytokines (IL-2, IL-7 and IL-21) to promote favorable anti-tumoral phenotypes in adoptive cellular therapies such as CAR-T cell therapy The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Bioactivity Assay:Proliferation of CTLL-2 ; ED50 =1 ng/mL; Bioactivity = 2x10^4 IU/ug