GM-CSF is a hematopoietic growth factor with the ability to form colonies of granulocytes and macrophages. • Enhances the number of circulating white blood cells and function of neutrophils and monocytes • Regulates multiple functions via transcription factors in the differentiated cells, including cell survival, proliferation, and maturation • Generates in vitro murine and human DC populations from bone marrow precursors and blood monocytes, respectively • Human and mouse GM-CSF do not show cross-reactivity The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Bioactivity Assay:Proliferation of TF-1; ED50 =0.2 ng/mL; Bioactivity =1.6 x 10^4 IU/µg