Brain-derived neurotrophic factor (BDNF) is a growth factor derived from the brain that binds to TrkB receptors, regulating neuronal growth, survival, and synaptic function. PG-003, an alternative peptide to BDNF, is a chemically-synthesized homodimeric cyclic peptide with specific binding ability against the TrkB receptor.
Upon binding, PG-003 induces dimerization of the TrkB receptor, triggering subsequent signaling events in cells as a TrkB agonist. It should be noted that PG-003 is believed to have no binding or agonistic activity towards the p75 receptor, which is a low-affinity nerve growth factor receptor that binds to BDNF. 10 µg of PG-003 exhibits equivalent activity to 25 µg of human BDNF.
Provided as lyophilized powder
Purity: greater than or equal to 95% (HPLC)
MW (Da): 5151.66 (acetate)
https://peptigrowth.com/en/products/pg-003/
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