5 mg
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D-AP5
Cayman ChemicalA selective NMDA receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors; widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.
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S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
MilliporeSigmaSynonyms: BBGC; BBGD; BrBzGCp2; N-[S-[(4-Bromophenyl)methyl]-N-L-gamma-glutamyl-L-cysteinyl]-Glycine dicyclopentyl ester; S-p-Bromobenzylglutathione dicyclopentyl ester; S-para-Bromobenzylglutathione cyclopentyl diester Molecular Formula: C27H38BrN3O6S Molecular Weight: 612.58 Linear…
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PF-05236216 hydrochloride >=98% (HPLC)
MilliporeSigmaSynonyms: 4-[3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-6-methyl-5H-pyrrolo[3,4-b]pyridin-5-one hydrochloride; PF-5236216 hydrochloride Molecular Formula: C18H15FN4O · HCl Molecular Weight: 358.8 Linear Structural Formula: C18H15FN4O · HCl Purity: >=98% (HPLC) …
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SB-258585 (hydrochloride)
Cayman ChemicalA potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53); has been used in cells and in animals.
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Cytosporone B
Cayman ChemicalA naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM); induces apoptosis in cancer cells and retards xenograft tumor growth; induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat/high cholesterol diet.
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ADT-OH
Cayman ChemicalA synthetic H2S donor that can be readily esterified with other moieties, including therapeutics and targeting motifs; used both in cells and in animals for comparative studies with derived chimeras.
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Hydroxy Linoleins
Cayman ChemicalHydroxy linoleins are a mixture of 132 possible isomers of mono-, di-, and tri-hydroxy compounds produced by the autoxidation of trilinolein and subsequent reduction of the hydroperoxides. Autoxidation of linoleic acid containing triglycerides (i.e., trilinolein) in vivo could result in the…
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A-77-01
Cayman ChemicalA-77-01 is a potent inhibitor of the TGF-β1 receptor ALK5 (IC50 = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-β on lung epithelial Mv1Lu cells. It completely blocks…
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Ochratoxin A
Cayman ChemicalA mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…
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Bosutinib
Cayman ChemicalBest known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively); can be effective in regulating tumor growth and differentiation; also inhibits other members of the Src and TEC families and certain other kinases at nanomolar concentrations.
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IWP-2
Cayman ChemicalAn inhibitor of Wnt production that impairs Wnt pathway activity (IC50 = 27 nM in vitro) by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins; used to suppress embryonic stem cell self-renewal and to decrease cancer cell proliferation,…
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Bioymifi
Cayman ChemicalA DR5 agonist (Kd= 1.2 µM; IC50 = 2 µM) that induces DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.
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Molecular Formula: C17D3H28NO6 · xLi+ Linear Structural Formula: C17D3H28NO6 · xLi+ Purity: >=95.0% (HPLC) Storage: -20C
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PF-6274484 >=98% (HPLC)
MilliporeSigmaSynonyms: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide Molecular Formula: C18H14ClFN4O2 Molecular Weight: 372.78 Linear Structural Formula: C18H14ClFN4O2 MDL Number: MFCD30182370 Purity: >=98% (HPLC) Storage: room temp Biochem Physiol…
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Fludarabine
Cayman ChemicalA nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.
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Acetoacetyl-L-carnitine chloride ; >/= 99% (TLC)
AFG BiosciencePurity Limit: ≥ 99% (TLC) Molecular Formula: C11H20O5NCl Molecular Weight: 00282 MDL No.: MFCD00274126 Appearance: White crystalline powder Storage Temperature: Store at 0-8 °C
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Serine Hydrolase Inhibitor-1
MilliporeSigmaSynonyms: tert-Butyl 4-(pyridin-2-ylcarbamoyl)piperazine-1-carboxylate; SHI-1 Molecular Formula: C15H22N4O3 Molecular Weight: 306.36 Linear Structural Formula: C15H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…
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HDMAPP (ammonium salt)
Cayman ChemicalA microbial metabolite that binds the TCR on Vγ9Vδ2 peripheral blood lymphocytes with high affinity (EC50 = 0.39 nM); induces the expansion of human memory Vγ9Vδ2 T cells.
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GSK2830371
Cayman ChemicalA potent and selective inhibitor of Wip1 (IC50 = 6 nM); increases phosphorylation of Wip1 substrates and blocks cell cycling in cancer cells; orally bioavailable, causing inhibition of lymphoma xenograft growth in mice.
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Ac-WEHD-AFC
Cayman ChemicalA fluorogenic substrate that can be cleaved specifically by group I caspases.
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3-Hydroxyglutaric Acid
Cayman ChemicalA metabolite produced during GCDH deficiency and used as a biomarker of glutaric acidemia type 1.
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PF-04620110
Cayman ChemicalA potent and selective inhibitor of DGAT-1 (IC50 = 19 nM); has high oral bioavailability (100%) in rats with a moderate half-life of 6.8 hours; significantly blocks an increase in plasma triglyceride levels following a corn oil bolus in rats.
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GDC-0032
Cayman ChemicalA potent inhibitor of PI3K isoforms α, δ, and γ (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ; has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo.
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TAK-632
Cayman ChemicalA selective slow off-rate inhibitor of Raf kinases (IC50s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively); shows significant antiproliferative activity against mutated BRAF or mutated NRAS cancer cell lines and xenograft models.
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NO-Indomethacin
Cayman ChemicalA hybrid molecule of indomethacin and an NO donor which combines the anti-inflammatory properties of an NSAID with the gastrointestinal protective effects of NO.
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[6]-Gingerol, >=98% (HPLC)
MilliporeSigmaSynonyms: 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-; 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; 6-Gingerol CAS Number: 23513-14-6 Formula: C17H26O4 Formula Weight: 294.39 Linear Formula: C17H26O4 MDL No.: MFCD00210507 Purity: >=98% (HPLC) Storage: …
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Fibronectin from Bovine Plasma
MP BiomedicalsFibronectin are adhesive glycoproteins and are found both as cell surface proteins and in plasma. They are large glycoproteins found in cells and extracellular fluids. They are involved in a wide range of biological activities including cell adhesion to extracellular matrices, blood coagulation and…
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Pepstatin A, 98%
Thermo Scientific ChemicalsFormula: C34H63N5O9 Formula weight: 685.90 Purity: 98% CAS Number: 26305-03-3 Harmonized Tariff Code: 2924.19
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MTSEA-biotin
Cayman ChemicalA thiol-reactive probe that can be used to label proteins at cysteine residues.
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Synonyms: Actinomycin C1; Actinomycin IV; Dactinomycin Formula: C62H86N12O16 Formula Weight: 1255.42 CAS No.: 50-76-0 Purity: ≥95% Storage Temperature: 2-8°C Application: Recommended for use in cell culture applications…