Synonyms: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
Molecular Formula: C18H14ClFN4O2
Molecular Weight: 372.78
Linear Structural Formula: C18H14ClFN4O2
MDL Number: MFCD30182370
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.